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Separation equipment and process method for purifying high-purity EPA-ee from fish oil

A separation device and high-purity technology, applied in the field of purifying high-purity EPA-ee in fish oil, can solve the problems of complex unsaturated fatty acid composition, low EPA purity, and high production cost, and achieve low concentration cost, high EPA yield, The effect of low production cost

Pending Publication Date: 2022-07-01
BEIJING CHUANGXIN TONGHENG SCI & TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Due to the complex composition of unsaturated fatty acids, there are many components similar to the chemical composition of EPA. If the sample amount is high, the purity of EPA is not high, and relevant impurities remain. It needs to be prepared and purified twice or even three times, but the more times of preparation, the total The lower the yield, the higher the production cost; the smaller the sample volume, the higher the purity of EPA, but the lower the processing capacity per unit filler, unit solvent and unit time, the higher the production cost

Method used

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  • Separation equipment and process method for purifying high-purity EPA-ee from fish oil

Examples

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Effect test

Embodiment 1

[0030] see figure 1 , according to a kind of separation equipment for purifying high-purity EPA-ee from fish oil according to an embodiment of the present invention, comprising an external fixing frame 1, the fixing frame 1 is provided with an infusion pump system 2, and the infusion pump system 2 is provided with In the valve control system 3 , four chromatographic columns 4 are symmetrically arranged on both sides of the fixed frame 1 , and an online monitoring device 5 is arranged at one end of the fixed frame 1 .

[0031] A kind of processing method of purifying high-purity EPA-ee from fish oil, is characterized in that, step is as follows:

[0032] S1: The low-content EPA-ee raw material needs to be purified to more than 60% by molecular distillation and other schemes;

[0033] S2: the ratio of regeneration liquid is 95%-100% methanol water, further 97-100% methanol water, and further 100% methanol water;

[0034] S3: the eluent ratio is 85%-95% methanol water, further ...

Embodiment 2

[0042] like figure 1 As shown, the bottom of the chromatographic column 4 is provided with support legs 7, which play a supporting role.

Embodiment 3

[0044] like figure 1 As shown, the online monitoring device 5 includes a control cabinet 6, which facilitates the overall control and real-time monitoring of the equipment.

[0045] In order to facilitate the understanding of the above technical solutions of the present invention, the working principle or operation mode of the present invention in the actual process will be described in detail below.

[0046] In practical application, the low content EPA-ee raw material needs to be purified to more than 60% through molecular distillation and other schemes. The purification process only uses methanol and water solvent, and the recovery and application are simple. The particle size of C18 filler is 10-50μm , a further 10-15μm, a further 15μm, the reversed-phase silica packing used in the super preparation has a good separation effect, the GMP / FDA certification is simple, and can be reused, the environmental pollution is small, the super chromatography purification process is fil...

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Abstract

The separation equipment comprises an outer fixing frame, an infusion pump system is arranged on the fixing frame, a valve control system is arranged on the infusion pump system, four chromatographic columns are symmetrically arranged on the two sides of the fixing frame, an on-line monitoring device is arranged at one end of the fixing frame, and a valve control system is arranged on the valve control system. The method has the beneficial effects that the filler separation effect is good, the filler can be recycled, the environmental pollution is small, the super chromatographic purification process is filled, the product concentration is high, the concentration cost is low, the weaving risk is small during product concentration, and the super chromatographic purification process is low in production cost, good in product quality, high in EPA yield, environmentally friendly and beneficial to industrial production.

Description

technical field [0001] The present invention relates to the technical field of purifying high-purity EPA-ee in fish oil, specifically, relate to a kind of separation equipment and processing method of purifying high-purity EPA-ee from fish oil. Background technique [0002] At present, the indications of fish oil extract drugs approved in China are blood lipid-lowering drugs, which have the effect of reducing serum triglycerides and total cholesterol, and are used for hyperlipidemia. The active ingredient is ethyl eicosapentaenoate (hereinafter referred to as EPA-ee). However, due to technological limitations, fish oil ethyl polyenoate drugs on the market are mixed. Most products have low purity and unstable impurities, resulting in unsatisfactory curative effects and even some cases of adverse reactions, which are far from international mainstream products. . [0003] Due to the complex composition of unsaturated fatty acids, there are many components similar to the chemi...

Claims

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Application Information

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IPC IPC(8): C07C51/42C07C51/44C07C51/47C07C57/03
CPCC07C51/42C07C51/44C07C51/47C07C57/03
Inventor 崔万臣危凤康小虎沈志刚李建伟牛顺超孙广志王靖宇
Owner BEIJING CHUANGXIN TONGHENG SCI & TECH
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