High-elasticity starch cavitary hemostatic material as well as use and preparation method thereof

A hemostatic material with high elasticity technology, applied in the field of biomedical materials, can solve the problems of fast degradation, poor water absorption, and inability to support hemostatic effect, etc., and achieve the effect of convenient acid removal, fine surface and uniform voids

Active Publication Date: 2022-07-12
江苏瀚仁生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method does not cross-link the sponge, its water absorption is poor, its degradation speed is fast, and its hemostatic effect cannot be supported

Method used

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  • High-elasticity starch cavitary hemostatic material as well as use and preparation method thereof
  • High-elasticity starch cavitary hemostatic material as well as use and preparation method thereof
  • High-elasticity starch cavitary hemostatic material as well as use and preparation method thereof

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preparation example Construction

[0042] The present invention further provides a method for preparing the above-mentioned highly elastic starch cavity hemostatic material, comprising the following steps:

[0043] Dissolve the feed liquid and fill it with an appropriate container; use the gradient cooling method to freeze-dry the product, put the freeze-dried sponge into a special container for high-temperature acid vapor cross-linking, and pulverize and sieve the cross-linked sponge. Then, the sponge powder is put into the carboxymethyl cellulose solution, and the product is freeze-dried by means of gradient cooling. The highly elastic starch cavity hemostatic material is obtained by packaging and sterilizing the freeze-dried product.

[0044] In the above-mentioned preparation method, its concrete steps are:

[0045] Step 1, dissolve the feed liquid; add one or more of the starch or its derivatives into the beaker, after swelling for 1-12 hours, heat it to 40-90 ° C, and slowly add other said other polymers...

Embodiment 1

[0068] The present embodiment provides a preparation method of a highly elastic starch cavity hemostatic material, the preparation method comprising the following steps:

[0069] 1. Add 100ml of purified water to the beaker, add 2g of sodium starch glycolate, swell for 2 hours, heat to 80°C, slowly add 3g of carboxymethyl chitosan under stirring, and continue stirring for 4 hours to fully dissolve the solution.

[0070] 2. After the solution described in step 1 is dissolved, pour it into freeze-drying containers according to different specifications, put the mold into the freezer, according to a, the temperature of the freezer is 1 ℃, and the time is 8h; b, the temperature of the freezer is -3℃, time is 15h; c, freezer temperature is -7℃, time is 8h; d, freezer temperature is -10℃, time is 20h; e, freeze dryer temperature is -55℃, time is 3h; f , the temperature of the lyophilizer partition is -15℃, and the time is 10h; g, the temperature of the lyophilizer partition is 0℃, an...

Embodiment 2

[0077] The present embodiment provides a preparation method of a highly elastic starch cavity hemostatic material, the preparation method comprising the following steps:

[0078] 1. Add 100ml of purified water and 3g of dextrin to the beaker. After swelling for 2 hours, heat to 50°C. Slowly add 4g of sodium carboxymethylcellulose under stirring, and continue stirring for 5 hours to fully dissolve the solution.

[0079] 2. After the solution described in step 1 is dissolved, pour it into freeze-drying containers according to different specifications, put the mold into the freezer, according to a, the temperature of the freezer is 1 ℃, and the time is 3h; b, the temperature of the freezer is -3℃, time is 6h; c, freezer temperature is -7℃, time is 9h; d, freezer temperature is -10℃, time is 20h; e, freeze dryer temperature is -55℃, time is 3h; f , the temperature of the lyophilizer partition is -15℃, and the time is 10h; g, the temperature of the lyophilizer partition is 0℃, and ...

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Abstract

The invention discloses a high-elasticity starch cavity hemostatic material and a use and preparation method thereof, the product is flexible and elastic, and the shape and the size of the product are designed according to different use parts. The preparation method comprises the following steps: dissolving starch and derivatives thereof and / or other macromolecular substances; then pouring into a corresponding container, and freezing and freeze-drying the product by using a gradient cooling method; carrying out high-temperature acid crosslinking on the freeze-dried product in an acid steam reactor; and packaging and sterilizing the product to obtain the final product. The high-elasticity starch cavity hemostatic material is stable in structure, smooth and fine in sample surface, high in liquid absorption capacity, relatively simple and convenient in manufacturing process, high in repeatability and high in product safety, and can be widely applied to the field of medical instruments. The product is degraded after being placed in the cavity 2-4 and flows out of the cavity, and secondary trauma of a patient caused by taking out the product after an operation is avoided.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to a high-elastic starch cavity hemostatic material and a preparation method thereof. Background technique [0002] There are many cavities in the human body, such as cavities, ear canals, vagina, etc. At the same time, there are also many sinus tracts caused by diseases or surgery itself. These cavities generally cause a large amount of bleeding during surgical treatment. Because of the deep bleeding points of cavity tract bleeding, it is difficult to perform hemostasis operations, thus causing great trouble to clinicians. Therefore, according to the particularity of the cavity, we developed a hemostatic material with high elasticity. Polyvinyl alcohol sponges are widely used in clinical markets, which have limited hemostatic effect and are not degradable, resulting in secondary injury and bleeding of patients during removal. The degradable material degrades on its own within ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08A61L24/00A61L24/10
CPCA61L24/08A61L24/102A61L24/104A61L24/0036A61L24/0042A61L2400/04Y02W90/10
Inventor 姚小祥黄晓峰刘国平
Owner 江苏瀚仁生物科技有限公司
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