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Deep vein thrombosis modeling device and method

A technology for deep vein thrombosis and modeling, which is applied in veterinary surgery, medical science, veterinary instruments, etc., can solve the problems of high failure rate of modeling experiments, high experience requirements, and increased mortality, so as to improve thrombus formation. rate, reduce the chance of infection, and avoid the effects of excessive blood loss

Pending Publication Date: 2022-07-15
SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] There are many methods for preparing animal models of deep vein thrombosis. At present, commonly used DVT modeling methods generally include inferior vena cava ligation, inferior vena cava stenosis, chemical methods (ferric chloride method), and electrolysis of inferior vena cava. Both require relatively large open surgery to expose animal blood vessels, which may easily cause infection and excessive blood loss in experimental animals, resulting in increased mortality, etc., and has great limitations.
At the same time, this method does not meet the pathogenesis of most DVT diseases and the causes of deep vein thrombosis caused by trauma in clinical practice. In addition, more operation steps in the above method need to be operated and completed manually, and the experience requirements for operators are relatively high. High, the failure rate of modeling experiments is high, therefore, there is an urgent need for a minimally invasive and effective modeling device and method

Method used

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  • Deep vein thrombosis modeling device and method
  • Deep vein thrombosis modeling device and method
  • Deep vein thrombosis modeling device and method

Examples

Experimental program
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Effect test

no. 1 example

[0065] In this embodiment, the deep vein thrombosis modeling device includes a scraper assembly and a main head 30, the scraper assembly includes an implanted tube 10 and a scraper disposed at the front end of the implanted tube 10, the Inserting the tube piece 10 can push the scraping piece to the modeling site of the blood vessel, and the main head 30 is located outside the body. The main head 30 is provided with a driving piece, and the output end of the driving piece is connected to the outside of the body. The implanted tube 10 is connected in a transmission. When the implanted tube 10 drives the rotary scraper to be inserted into the animal, the driving member drives the rotary scraper in the blood vessel by driving the implanted tube 10 to rotate. Rotating so that the scraper causes mechanical damage to the inner wall of the blood vessel during the rotating process, so that the blood vessel forms a thrombus at the modeling site. Specifically, in order to drive the inser...

no. 2 example

[0081] In order to further improve the modeling efficiency and success rate, the deep vein thrombosis modeling device is also provided with a drug delivery member, and the drug delivery member can deliver the coagulation-promoting drug to the modeling site to further promote modeling The site of thrombosis, specifically, the drug delivery element includes a drug-loaded balloon and a drug coating at least partially covering the outer surface of the drug-loaded balloon, the drug coating comprising a carrier and a drug loaded on the carrier. For procoagulant drugs, the carrier can be selected from the prior art, preferably polyethylene glycol. When the balloon body 20 is placed in the modeling site, the procoagulant drug can be detached from the carrier and dispersed in the blood.

[0082] The difference between this embodiment and Embodiment 1 is that the drug-carrying function of the balloon body 20 can also be achieved in the following manner. At least one sealing membrane 70 ...

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Abstract

The invention relates to the technical field of deep vein thrombosis modeling, in particular to a deep vein thrombosis modeling device and method.The deep vein thrombosis modeling device comprises a rotary scraping assembly and a main head.The rotary scraping assembly comprises an imbedding pipe and a rotary scraping piece arranged at the front end of the imbedding pipe; the rotary scraping piece can be pushed to a modeling site of a blood vessel by the imbedding pipe fitting; a driving part is arranged in the main machine head, the output end of the driving part is in transmission connection with the imbedding pipe fitting, and the driving part is used for driving the imbedding pipe fitting to rotate and driving the rotary scraping part to rotate in the blood vessel so that the rotary scraping part can cause mechanical damage to the inner wall of the blood vessel in the rotating process. Therefore, deep vein thrombosis is formed in the modeling blood vessel by causing mechanical damage to the blood vessel wall, the operation is convenient, and the modeling success rate and the modeling efficiency can be effectively improved.

Description

technical field [0001] The invention relates to the technical field of deep vein thrombosis modeling, in particular to a deep vein thrombosis modeling device and method. Background technique [0002] Deep venous thrombosis (DVT) is a thrombus that forms in the deep veins, usually in the veins deep in the lower extremities or pelvis, and sometimes in the veins in the upper extremities. When DVT occurs, the limbs are usually painful, swollen, red, and hot, which may cause the superficial veins to swell, but sometimes there may be no symptoms. Recent studies have shown that asymptomatic DVT is not uncommon in clinical practice. The most serious complication of DVT is a blood clot that breaks off and enters the lungs, causing a pulmonary embolism. [0003] The causes of venous thrombosis are complex, and the treatment of DVT mainly includes anticoagulation therapy and interventional therapy. At present, the specific signal transduction pathway for the occurrence and developmen...

Claims

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Application Information

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IPC IPC(8): A61D1/00A61M25/10
CPCA61D1/00A61M25/104A61M2250/00
Inventor 刘晓兵胡佳腾刘光赵振李逢时仇鹏秦金保陆信武
Owner SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE