Application of medium-chain fatty acid monoglyceride composition in preparation of products for promoting bone growth

A technology of medium-chain fatty acid and caprylic monoglyceride, applied in products, in the field of medium-chain fatty acid monoglyceride composition, to achieve good practicability, increase bone density, and promote bone growth

Pending Publication Date: 2022-07-15
浙江大学中原研究院 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no safe and effective method to completely restore the loose bone to its normal bone mass and structure. Therefore, the development of a natural source of medium-chain fatty acid monoglyceride composition

Method used

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  • Application of medium-chain fatty acid monoglyceride composition in preparation of products for promoting bone growth
  • Application of medium-chain fatty acid monoglyceride composition in preparation of products for promoting bone growth
  • Application of medium-chain fatty acid monoglyceride composition in preparation of products for promoting bone growth

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] To verify the effect of MCMGS (weight ratio of lauric acid monoglyceride, capric acid monoglyceride and caprylic acid monoglyceride, 3:1:1, 750 mg / kg) on ​​zebrafish spine length, bone mineral density and bone phenotype, It can be understood that the ratio in brackets is the weight ratio of lauric acid monoglyceride, capric acid monoglyceride and caprylic acid monoglyceride in MCMGs, and the dose in brackets is the administered dose of MCMGs. The subsequent examples are based on this reasoning, not Repeat.

[0055] experimental method

[0056] A total of 144 three-month-old AB-type zebrafish with healthy physique and consistent specifications were selected and randomly divided into 2 groups after pre-rearing for 7 days, the control group (CON) and the experimental group (MCMGS). 16:00), were fed basal feed and custom basal feed containing 750mg / kg MCMGS, the experimental period was 8 weeks. Each group of 4 repetitions, each repetition of 18 fish, were placed in 8 10L ...

Embodiment 2

[0061] To verify the effect of MCMGS (weight ratio of lauric acid monoglyceride, capric acid monoglyceride and caprylic acid monoglyceride, 2:1:0.5, 1500 mg / kg) on ​​zebrafish spine length, bone mineral density and bone phenotype.

[0062] experimental method

[0063] It is roughly the same as Example 1, except that the ratio of MCMGs and the administered dose are 1500 mg / kg.

[0064] Experimental results

[0065] After obtaining a large number of bone indexes, referring to the method of Hur et al., using Z-score analysis, the bone indexes of each vertebra were standardized, as follows: For a certain bone index of each part, the value of the index was compared with that of the control group. The difference between the means of all vertebrae was divided by the standard deviation of all vertebrae in the control group. These normalized data are then visualized to generate heatmaps ( image 3 ) to compare trends in skeletal phenotypes. Through the heat map of phenotype, it can...

Embodiment 3

[0069] To verify the effect of MCMGS (weight ratio of lauric acid monoglyceride, capric acid monoglyceride and caprylic acid monoglyceride is 1:1:0.1, 150 mg / kg) on ​​the expression of bone metabolism-related genes in zebrafish.

[0070] experimental method

[0071] It is roughly the same as Example 1, except that the ratio of MCMGs (1:1:0.1), its administration dose is 150 mg / kg, and the detected index is the expression of bone metabolism-related genes.

[0072] Experimental results

[0073] The results of skeletal phenotype showed that the improvement effect of 150mg / kg MCMGS on zebrafish bone development was mainly concentrated in the caudal part of the spine, which significantly promoted the bone development and mineral deposition in the caudal part. To further explore the regulatory effect of MCMGS on bone formation in the caudal vertebra of zebrafish, this study detected osteogenic marker genes in the caudal vertebra, such as Figure 5 shown. The expressions of runx2b...

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Abstract

The invention discloses application of a medium-chain fatty acid monoglyceride composition in preparation of a product for promoting bone growth, and relates to the technical field of medicines and health care products. The invention researches the influence of medium-chain fatty acid on bone growth and bone metabolism by utilizing a high-throughput proteomics technology, and finds that the composition of lauric acid monoglyceride, capric acid monoglyceride and caprylic acid monoglyceride can promote bone growth, increase bone density and improve bone metabolism. A safe and healthy intervention scheme is provided for patients with osteoporosis, chronic obstructive pulmonary diseases and metabolic disorders related to reduction of bone mineral density, and the method has excellent practicability.

Description

technical field [0001] The invention relates to the technical field of medicine and health care products, in particular to the application of a medium-chain fatty acid monoglyceride composition in the preparation of a product for promoting bone growth. Background technique [0002] Bone health has received a lot of attention in recent years. Bone mineral density (BMD) is an important indicator of bone strength and an important basis for reflecting the degree of osteoporosis and predicting the risk of fractures. Measuring BMD is simple and quick, and is one of the main methods for detecting bone conditions. [0003] According to epidemiological studies, the number of osteoporosis patients has increased significantly, and its incidence has jumped to the forefront of common and frequently-occurring diseases. The latest research shows that osteoporosis, which has long been considered a disease specific to the elderly, actually exists in childhood. [0004] In addition, the stu...

Claims

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Application Information

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IPC IPC(8): A61K31/23A61P19/10A23L33/12
CPCA61K31/23A61P19/10A23L33/12A23V2002/00A61K2300/00A23V2200/306A23V2250/192
Inventor 冯凤琴莫秋芬刘滔汪愈超
Owner 浙江大学中原研究院
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