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Application of osteocalcin in preparation of anti-inflammatory drugs

An anti-inflammatory drug, osteocalcin technology, applied in the field of biomedicine, can solve the problems of unclear regulation and lack of anti-inflammatory research on osteocalcin, and achieve the goal of preventing inflammatory diseases, inhibiting the release of inflammatory factors, and delaying the occurrence and development Effect

Pending Publication Date: 2022-07-15
SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the function of osteocalcin in macrophages, especially whether it has a regulatory effect on macrophage inflammatory response is still unclear
[0004] Therefore, there is still a lack of anti-inflammatory research on osteocalcin, and the inhibition of inflammation and the development of related diseases through osteocalcin remains to be further elucidated

Method used

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  • Application of osteocalcin in preparation of anti-inflammatory drugs
  • Application of osteocalcin in preparation of anti-inflammatory drugs
  • Application of osteocalcin in preparation of anti-inflammatory drugs

Examples

Experimental program
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Effect test

Embodiment 1

[0034] 1. In vitro cell experiment: The mouse macrophage cell line RAW264,7 and primary bone marrow-derived macrophages were used as the research objects, and the macrophages were infected with osteocalcin polypeptide synthesized in vitro, and then the macrophage inflammation was analyzed. expression of related factors.

[0035] 1. Isolation and culture of peritoneal macrophages

[0036] 1) 6-8 week old mice were used for cell isolation, and 4% sodium thioglycollate (thioglycollate broth, Sigma-Aldrich, Cat#70157) was intraperitoneally injected three days before the experiment, 4 mL per mouse;

[0037] 2) Mice were sacrificed by de-neck, soaked in 75% alcohol for 1-2 minutes, transferred to a clean table, fixed on a dissection board in a supine position, sterilized the abdominal skin with iodine, and de-iodized with alcohol sponges. Fully cut the abdominal skin with surgical straight scissors to expose the abdominal muscle layer, and then disinfect the abdominal muscle layer ...

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Abstract

The invention discloses an application of osteocalcin in preparation of an anti-inflammatory drug. The invention provides application of osteocalcin in preparation of drugs for inhibiting expression and / or release of macrophage inflammatory factors and / or promoting expression and / or release of macrophage anti-inflammatory factors. The invention finds that osteocalcin has anti-inflammatory activity, based on the application of osteocalcin in preparation of anti-inflammatory drugs and drugs for treating and / or preventing inflammation-related diseases, osteocalcin is supplemented from an external source, so that the functions of macrophages are specifically regulated, and the release of inflammatory factors is inhibited, thereby preventing inflammatory diseases caused by the macrophages; the occurrence and development of inflammation are delayed.

Description

technical field [0001] The invention belongs to the field of biomedicine, and particularly relates to the application of osteocalcin in the preparation of anti-inflammatory drugs. Background technique [0002] Osteocalcin is a polypeptide hormone composed of 46-55 amino acids secreted by osteoblasts. Osteocalcin exists mainly in two forms: fully carboxylated and undercarboxylated. The former is mainly deposited in the bone matrix as a structural component, while the latter acts on multiple peripheral organs other than the bone and the central nervous system through the blood circulatory system, and has a very important regulatory role in maintaining various physiological functions and the body's homeostasis. For example, osteocalcin can act on the pancreas to promote insulin production and β-islet cell proliferation, thereby regulating the body's energy metabolism; in the male reproductive system, osteocalcin can act on the testosterone synthase in the Leydig cells (leydig ...

Claims

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Application Information

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IPC IPC(8): A61K38/22A61P29/00A61P3/10A61P3/04A61P3/00A61P9/00A61P1/00A61P25/00A61P35/00A61P31/04A61P31/12
CPCA61K38/22A61P29/00A61P3/10A61P3/04A61P3/00A61P9/00A61P1/00A61P25/00A61P35/00A61P31/04A61P31/12
Inventor 钱政江李翔
Owner SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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