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Drug coating, drug balloon and preparation method and application of drug balloon

A drug coating and drug technology, applied in coatings, catheters, etc., can solve the problems of difficulty in ensuring the retention time of drug balloons, and difficulty in controlling the crystallization state of drug coatings, so as to simplify the formula selection process, prolong the retention time, and improve the The effect of efficiency

Active Publication Date: 2022-07-15
LEPU MEDICAL TECH (BEIJING) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Therefore, the technical problem to be solved by the present invention is to overcome the defects that most of the drug coatings obtained by the formula in the prior art are difficult to control their crystallization state, and it is difficult to ensure the retention time of drug balloons in the treatment of blood vessels or other lumen stenosis diseases.

Method used

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  • Drug coating, drug balloon and preparation method and application of drug balloon
  • Drug coating, drug balloon and preparation method and application of drug balloon

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The present embodiment provides a drug coating, which includes a drug and a carrier, the drug is paclitaxel, the carrier is tea polyphenol, the solvent is acetone, the mass ratio of the drug and the carrier is 25:1, and the mass ratio of the drug and the solvent is 30: 1.

[0038] This embodiment provides a drug balloon, which is obtained by coating the aforementioned drug coating on the surface of the balloon. The specific preparation method includes the following steps:

[0039] S1. Dissolve the drug and the carrier into the solvent, then stir for 3 min, ultrasonically vibrate for 15 min, the ultrasonic frequency is 100 Hz, the temperature is 30 °C, and then the oscillated solution is allowed to stand for 0.5 h;

[0040] S2. Spray the solution onto the surface of the balloon by ultrasonic spraying; the spraying pressure is 0.01MPa, the spraying flow rate is 0.03mL / min, and the nominal dose of the balloon obtained by spraying is 1μg / mm 2 .

Embodiment 2

[0042] This embodiment provides a drug coating, which includes a drug and a carrier, the drug is paclitaxel, the carrier is maltol, the solvent is acetone, the mass ratio of the drug to the carrier is 20:1, and the mass ratio of the drug to the solvent is 30:1 .

[0043] This embodiment provides a drug balloon, which is obtained by coating the aforementioned drug coating on the surface of the balloon. The specific preparation method includes the following steps:

[0044] S1. Dissolve the drug and the carrier into the solvent, then stir for 3 min, ultrasonically vibrate for 15 min, the ultrasonic frequency is 100 Hz, and the temperature is 30 °C, and then the oscillated solution is allowed to stand for 1 h;

[0045] S2. Spray the solution onto the surface of the balloon by ultrasonic spraying; the spraying pressure is 0.01MPa, the spraying flow rate is 0.03mL / min, and the nominal dose of the balloon obtained by spraying is 1μg / mm 2 .

Embodiment 3

[0047] This embodiment provides a drug coating, which includes a drug and a carrier, the drug is paclitaxel, the carrier is eugenol, the solvent is acetonitrile, the mass ratio of the drug to the carrier is 1:10, and the mass ratio of the drug to the solvent is 500:1 .

[0048] This embodiment provides a drug balloon, which is obtained by coating the aforementioned drug coating on the surface of the balloon. The specific preparation method includes the following steps:

[0049] S1. Dissolve the drug and the carrier into the solvent, then stir for 3 min, ultrasonically vibrate for 15 min, the ultrasonic frequency is 100 Hz, and the temperature is 30 °C, and then the oscillated solution is allowed to stand for 1 h;

[0050] S2. Spray the solution onto the surface of the balloon by ultrasonic spraying; the spraying pressure is 0.01MPa, the spraying flow rate is 0.03mL / min, and the nominal dose of the balloon obtained by spraying is 1μg / mm 2 .

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Abstract

The invention provides a drug coating, a drug balloon and a preparation method and application of the drug balloon. The drug coating for the drug balloon comprises a drug and a carrier, the carrier is a phenolic compound or a pyrone compound, and the mass ratio of the drug to the carrier is 1: (0.01-10). The drug balloon is obtained by coating the drug coating on the surface of the balloon. The phenolic compound or the pyrone compound is used as a new carrier, so that the carrier selection efficiency of the drug coating is improved, an ideal crystal form can be obtained, the quality of the drug coating is remarkably improved, the retention time of the drug during treatment of blood vessel or other lumen stenosis diseases is prolonged, and the drug coating has a good application prospect. Therefore, when the medicine balloon catheter is used for treating blood vessel, urethra or ureteral stenosis, the restenosis of the lumen can be better inhibited.

Description

technical field [0001] The invention relates to the technical field of drug balloons, in particular to a drug coating, a drug balloon and a preparation method and application of the drug balloon. Background technique [0002] The drug balloon catheter is an interventional medical device consisting of a catheter and a drug balloon. The drug balloon consists of a balloon and a drug coating coated on its surface. The drug balloon catheter is mainly used for the expansion of the stenotic part of the blood vessel. It releases the drug to the intima of the blood vessel while expanding the blood vessel, and plays the role of inhibiting the restenosis of the blood vessel. [0003] The formulation of the drug coating generally includes a drug and a carrier. The drug balloon can be obtained by dissolving the drug and the carrier in a solvent and then coating the surface of the balloon. At present, in domestic and foreign technologies, the carriers used to obtain drug balloons are ge...

Claims

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Application Information

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IPC IPC(8): A61L29/08A61L29/14A61L29/16
CPCA61L29/08A61L29/14A61L29/16A61L2420/02A61L2420/06A61L2300/606A61L2300/416
Inventor 马翠杰赵丽晓刘扬扬何智浩王哲
Owner LEPU MEDICAL TECH (BEIJING) CO LTD
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