Chromatographic analysis method of dehydroevodiamine

A technique for dehydroevodiamine and chromatographic analysis, which is applied in the field of chromatographic analysis, can solve problems such as tailing, and achieves the effects of convenient operation, simple analysis conditions and simple preparation.
CN114778751APending Publication Date: 2022-07-22JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
Publication Date
2022-07-22

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Abstract

The invention discloses a chromatographic analysis method for thoroughly solving the peak shape of a dehydroevodiamine chromatographic peak, which adopts reversed-phase high performance liquid chromatography, takes hydrochloric acid as an additive for the first time, adjusts the pH value of a mobile phase to be 1-2, remarkably improves the problem of trailing of the dehydroevodiamine chromatographic peak, has simple analysis conditions, is convenient to operate, and is suitable for industrial production. The chromatographic mobile phase additive is economical and environment-friendly; symmetry factors of chromatographic peaks meet requirements of Chinese pharmacopoeia, and chromatographic analysis conditions can be used for measuring the content of dehydroevodiamine in medicinal materials, Chinese patent medicines and biological samples of fructus evodiae.
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Description

technical field

[0001] The invention relates to the technical field of chromatographic analysis methods, in particular to a chromatographic analysis method for dehydroevodiamine. Hydrochloric acid is added to a chromatographic mobile phase to make the pH of 1-2, so as to completely solve the chromatographic peak tailing of dehydroevodiamine. question. Background technique

[0002] Dehydroevodiamine (DHED) is an indole alkaloid with high pharmacological activity isolated from the Rutaceae plant Evodia, mainly exists in Rutaceae ( Rutaceae ) in the fruit of the plant Evodia, is the characteristic component of the plant. Modern pharmacological studies have shown that dehydroevodiamine has various pharmacological activities such as anti-inflammatory, antiemetic, dilating blood vessels, slowing heart rate, lowering blood pressure, and neuroprotection. 2011, 29(11): 2415-2417; Hepatotoxicity comparison of crude andlicorice-processed euodiae fructus in rats with stomach excess-co...

Claims

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