Water-soluble salicylic acid as well as preparation method and application thereof

A salicylic acid and water-soluble technology, which is applied in the field of water-soluble salicylic acid and its preparation, can solve the problems of restricting the wide use of salicylic acid, poor water solubility of salicylic acid, and difficulty in adding it, and achieve good economic benefits and water-soluble Strong, less irritating effect

Pending Publication Date: 2022-07-29
SHANDONG BINZHOU ZHIYUAN BIO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Salicylic acid is a small molecular organic acid with strong permeability and can stimulate deep skin and nerves. At the same time, salicylic acid has poor water solubility and is difficult to add, which limits the wide use of salicylic acid in cosmetics

Method used

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  • Water-soluble salicylic acid as well as preparation method and application thereof
  • Water-soluble salicylic acid as well as preparation method and application thereof
  • Water-soluble salicylic acid as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Weigh sorbic acid (40g, 0.36mol) and dissolve it in 160g deionized water, heat it to 50°C, add salicylic acid (50g, 0.36mol) in 10 times, stir for 1h after feeding, and add 35g methyl-β after fully reacting - Cyclodextrin, kept at 50°C for 3h, and spray-dried under the following drying conditions: feed temperature 170°C, sample injection flow rate 20mL / min, air flow rate 0.3MPa air pressure, and discharge temperature 80°C; water-soluble water was obtained Sylic acid. The infrared spectrum of water-soluble salicylic acid is as follows figure 1 As shown, the scanning electron microscope picture is as figure 2 shown, figure 1 For the infrared spectrum of water-soluble salicylic acid in Example 1, figure 2 SEM image of water-soluble salicylic acid in Example 1.

[0032] figure 1 The results showed that due to the formation of dimer acid and the influence of intermolecular hydrogen bonds, the carboxyl peak of the prepared water-soluble salicylic acid shifted to the ri...

Embodiment 2

[0035] Weigh lactic acid (40g, 0.44mol), dissolve it in 200g deionized water, heat it up to 55°C, add salicylic acid (50g, 0.36mol) in 8 times, stir for 1h after feeding, and add 35g methyl-β- Cyclodextrin was kept at 55°C for 3h, and spray-dried under the following drying conditions: the feed temperature was 170°C, the injection flow rate was 20mL / min, the air flow rate was 0.3MPa, and the discharge temperature was 80°C; acid.

Embodiment 3

[0037] Weigh gluconic acid (4kg, 20.39mol) and dissolve it in 20kg deionized water, heat up to 55°C, add salicylic acid (5kg, 36.23mol) in 12 times, stir for 1h after feeding, and add 3.5kg methyl- β-cyclodextrin was kept at 55°C for 5 hours, and spray-dried to obtain water-soluble salicylic acid. The drying conditions are: the feed temperature is 170°C, the sample injection flow rate is 20mL / min, the air flow rate is the air pressure of 0.3MPa, and the discharge temperature is 80°C; water-soluble salicylic acid is obtained.

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Abstract

The invention provides water-soluble salicylic acid as well as a preparation method and application thereof. The water-soluble salicylic acid comprises dimer acid and cyclodextrin, wherein the dimer acid is formed by salicylic acid and organic acid. The preparation method comprises the following steps: mixing active components salicylic acid and organic acid to react, forming dimer acid in a non-covalent bond form, and interacting the dimer acid with cyclodextrin to obtain the water-soluble salicylic acid. The water-soluble salicylic acid obtained by the invention is high in water solubility and good in water solution stability, and relatively high solubility of salicylic acid is ensured while the addition amount of cyclodextrin is reduced. According to the invention, the water-soluble salicylic acid is applied to the fields of skin beautifying, washing and care and medicines, so that the release of the salicylic acid and the concentration of the salicylic acid on the skin surface can be better controlled.

Description

technical field [0001] The invention belongs to the technical field of skin care products, in particular to a water-soluble salicylic acid and a preparation method and application thereof. Background technique [0002] Salicylic acid is a white crystalline powder that exists in willow bark, white pearl leaves and sweet birch in nature. Salicylic acid has excellent ability to exfoliate and clean pores, and can achieve the effects of lightening pigment spots, removing fine wrinkles, improving sun-induced aging, shrinking pores and removing acne. At the same time, salicylic acid is highly safe, making it a skin care product. New darling. Salicylic acid can dissolve the constitutive substances between the cuticles and make the cuticles fall off, so it can remove the accumulated thick cuticles and promote metabolism. [0003] When the concentration of salicylic acid is 3% to 6%, it can be used for exfoliation, and the concentration above 6% is destructive to the tissue. When t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/368A61K8/365A61K8/44A61K8/73A61Q19/00A61Q19/10A61Q5/02A61Q19/02A61P17/10
CPCA61K8/368A61K8/365A61K8/44A61K8/738A61Q19/00A61Q19/10A61Q5/02A61Q19/02A61P17/10
Inventor 李鹏程王波梁宁宁申健
Owner SHANDONG BINZHOU ZHIYUAN BIO TECH CO LTD
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