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Biosensor based on organic electrochemical transistor and detection method

A biosensor and transistor technology, applied in the field of ion detection, can solve the problems of increasing the complexity of the device structure, etc., and achieve the effects of reducing performance differences, improving stability, and reducing swelling

Pending Publication Date: 2022-07-29
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

For example, the use of materials with specific chemical functions, or ion-permeable membranes with selective functions, but this will undoubtedly increase the complexity of device fabrication steps and device structures

Method used

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  • Biosensor based on organic electrochemical transistor and detection method
  • Biosensor based on organic electrochemical transistor and detection method
  • Biosensor based on organic electrochemical transistor and detection method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0062] The concrete steps of using OECT of the present invention to detect ions are as follows:

[0063] (1) Preparation of organic electrochemical transistors for ion detection: gold source-drain electrodes were evaporated on a silicon dioxide substrate, and 1% EG, 2% GOPS, and 0.1% DBSA were added to the PH1000 solution, respectively. The stirred solution was diluted with deionized water at a ratio of 1:0.5, and the final solution was spin-coated on the substrate of the evaporated gold electrode, then annealed on a hot stage, and finally soaked in DMSO solution for 30 min. , to obtain biosensors based on organic electrochemical transistors;

[0064] (2) Use tweezers to scrape off the film except for the channel, and use a syringe to transfer 5 μL of different concentrations (10 -4 to 1mol / L) NaCl, KCl, MgCl 2 , CaCl 2 The electrolyte solution was added dropwise to the surface of the channel, the source-drain probe was fixed on the source-drain electrode of the OECT, and t...

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Abstract

The biosensor comprises a silicon dioxide substrate, gold material electrodes serving as a source electrode and a drain electrode of the organic electrochemical transistor are arranged on the two sides of the silicon dioxide substrate, and a channel formed between the two gold material electrodes is coated with a diluted channel material PEDOT: PSS in a spinning mode. According to the method, the biosensor is manufactured by utilizing the specific ion electron transduction characteristic of the OECT, and through the time response of the device, on the premise that the preparation steps of the device are not increased, the yield of the device is improved, and the yield of the device is improved. And various ions are detected on the same device.

Description

technical field [0001] The invention belongs to the technical field of ion detection, in particular to a biosensor and a detection method based on an organic electrochemical transistor. Background technique [0002] Biosensors are analytical devices used to detect biological substances such as proteins, DNA, antibodies, enzymes, tissues, microorganisms and organelles. Due to the advantages of organic materials such as low cost, high flexibility, easy preparation and good biocompatibility, organic transistors have broad application prospects in the field of biosensors. Organic electrochemical transistors (OECTs) not only exhibit more stable performance in liquid environments, but also have lower operating voltages (usually less than 1 V). This feature of being able to operate in an electrolyte makes it suitable for a variety of sensing, especially in situ measurements. [0003] Current commercial sensors focus primarily on tracking physical parameters such as heart rate, te...

Claims

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Application Information

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IPC IPC(8): G01N27/414
CPCG01N27/4145
Inventor 马伟王二慧赵超王世杰
Owner XI AN JIAOTONG UNIV
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