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Hard mask repairing patch capable of being sewn and pasted as well as preparation method and application of hard mask repairing patch

A technology of patch and dura mater, applied in the field of suturable and affixable dura mater repair patch and its preparation, can solve the problems of poor adhesion between biofilm and tissue, unfavorable defect repair, single use method, etc., and achieve excellent The effect of suture performance, smooth surface, and simple preparation method

Pending Publication Date: 2022-08-02
BEIJING YH BIOMAX BIOLOGIC TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The biofilm sheet has a highly open pore structure, so it has good adhesion performance, but its mechanical properties are weak, so it cannot be sutured, so the method of use is relatively simple
In addition, chondroitin sulfate is also added to the biofilm sheet, which will cause the biofilm sheet to not fit firmly with the tissue, and it is easy to slide, which is not conducive to defect repair

Method used

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  • Hard mask repairing patch capable of being sewn and pasted as well as preparation method and application of hard mask repairing patch
  • Hard mask repairing patch capable of being sewn and pasted as well as preparation method and application of hard mask repairing patch
  • Hard mask repairing patch capable of being sewn and pasted as well as preparation method and application of hard mask repairing patch

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0058] The preparation method of the above-mentioned sewable and stickable dura mater repair patch, such as figure 1 shown, including the following steps:

[0059] (1) Dispersion; disperse type I collagen in an acidic medium to prepare a type I collagen slurry with a concentration of 0.8-2%; wherein, the type I collagen is type I collagen with triple helix structure; the acidic medium The pH is 2-5; the acidic medium is selected from acetic acid and hydrochloric acid.

[0060] (2) Homogenization: a homogenizer connected to a vacuum system is used to homogenize the type I collagen slurry and remove air bubbles to obtain a homogeneous type I collagen slurry; the homogenization frequency of the homogenizer is 20-60 Hz , the number of cycles is 5-20 times, the time of homogenization is 5min-1h, and the temperature of homogenization is 0-20°C.

[0061] (3) Freeze-drying: First, pour the homogenous type I collagen slurry into the mold to ensure that the amount of the homogenous ty...

Embodiment 1-3

[0067] Embodiments 1-3 respectively provide a preparation method of a sewable and stickable dura mater repair patch.

[0068] The difference between the above embodiments is: in the dispersion step, the concentration of the type I collagen slurry is specifically shown in Table 1.

[0069] The preparation method of the sewable and stickable dura mater repair patch provided by embodiment 2 specifically comprises the following steps:

[0070] (1) Dispersion: Disperse the triple-helix type I collagen in a 0.05M acetic acid solution to prepare a type I collagen slurry with a concentration of 1.5%.

[0071] (2) Homogenization: a homogenizer connected with a vacuum system is used to homogenize the type I collagen slurry and remove air bubbles to obtain a homogeneous type I collagen slurry; the homogenization frequency of the homogenizer is 40 Hz, and the cycle The number of times is 5, the time of homogenization is 10min, and the temperature of homogenization is 5°C.

[0072] (3) F...

Embodiment 4-7

[0077] Embodiments 4-7 respectively provide a preparation method of a seamable and stickable dura mater repair patch.

[0078] The difference between the above embodiment and Embodiment 2 is that: in the homogenization step, the homogenization frequency of the homogenizer is specifically shown in Table 2.

[0079] The homogenization frequency of the homogenizer in the preparation method provided in Table 2 Example 2 and Example 4-7

[0080] Example Homogeneous frequency (Hz) 2 40 4 10 5 20 6 60 7 70

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Abstract

The invention relates to the technical field of tissue engineering and regenerative medicine, and particularly discloses a dura mater repair patch capable of being sewn and pasted as well as a preparation method and application of the dura mater repair patch. The preparation method of the dura mater repair patch capable of being sewn and pasted comprises the steps of dispersing, homogenizing, freeze drying, cross-linking sterilization and the like. The dura mater repair patch capable of being sewn and pasted is prepared by using the method; the invention further discloses application of the dura mater repair patch capable of being sewn and pasted to dura mater and spinal mater tissue repair. The dura mater repair patch capable of being sewn and attached can repair damage and defects of dura mater and spinal mater tissue in a sewing or attaching mode, and is good in sewing performance and attaching effect.

Description

technical field [0001] The present application relates to the technical field of tissue engineering and regenerative medicine, in particular to a sutureable and stickable dural repair patch and a preparation method and application thereof. Background technique [0002] In recent years, complications such as cerebrospinal fluid leakage, infection, postoperative adhesion of dural tissue to brain tissue or spinal cord, and even epilepsy caused by trauma or other diseases such as tumors, cerebral vascular malformations, etc. more and more. In medicine, dural injury or defect is repaired with dural repair materials. The most commonly used dural repair material is autologous membrane, but the source of autologous membrane is limited, the operation is complicated, and it will cause new trauma, so it is only suitable for repairing small Area defects, and large area defects are usually completed by other dura mater replacement materials. [0003] Current dural replacement materials...

Claims

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Application Information

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IPC IPC(8): A61L27/24A61L27/50A61L27/56
CPCA61L27/24A61L27/50A61L27/56A61L2430/40A61L2430/32
Inventor 张艳勤吴梦妍
Owner BEIJING YH BIOMAX BIOLOGIC TECH
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