Hydrogel microneedle patch for noninvasive blood glucose detection as well as preparation method and application of hydrogel microneedle patch

A blood sugar detection and hydrogel technology, which is applied in the field of biomedical research, can solve the problems of skin irritation, seldom, pain, etc., and achieve the effects of rapid response, simple preparation steps, and easy process conditions.

Pending Publication Date: 2022-08-05
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although reverse iontophoresis is the most common of these methods, it is currently rarely recognized by physicians in the context of blood glucose correlation
In addition, the use of high-density current and long-term warm-up often cause skin irritation and pain for users

Method used

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  • Hydrogel microneedle patch for noninvasive blood glucose detection as well as preparation method and application of hydrogel microneedle patch
  • Hydrogel microneedle patch for noninvasive blood glucose detection as well as preparation method and application of hydrogel microneedle patch
  • Hydrogel microneedle patch for noninvasive blood glucose detection as well as preparation method and application of hydrogel microneedle patch

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Embodiment 1

[0044] 1. Preparation of pH-responsive hydrogel CMC-pHEA

[0045] First, put 50ml of distilled water and carboxymethyl cellulose (CarboxyMethy1 Cellulose, CMC) (5.56×10mol) into a 250m1 three-neck round-bottom flask at 75°C (50-100°C, preferably 75°C) and 400rpm (300- 500rpm, preferably 400rpm) in a water bath with stirring until the CMC is fully dissolved. Then nitrogen was injected into the partial pressure bottle containing the CMC solution for 20 minutes to fully reduce the oxygen content in the solution, and then potassium persulfate (KPS, 1.85×105mol) was added to the solution as an initiator to mix the reaction for 20 minute. Next, 3.92×10 mol of 2-hydroxyethyl acrylate (2-HydroxyEthy1 Acrylate, 2-HEA) was added. When the reaction mixture became milky white, 0.32×10mol crosslinking agent polyethylene glycol diacrylate PEGDA was added, and the reaction was continued for 3 hours. After the reaction was completed, it was fully cooled at room temperature. The stirring sp...

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Abstract

The invention discloses a hydrogel microneedle patch for noninvasive blood glucose detection as well as a preparation method and application of the hydrogel microneedle patch. According to the invention, the microneedle patch is prepared by a turnover technology and is noninvasively applied to the skin surface, so that simple and rapid extraction of interstitial fluid in vivo and a new method for real-time, rapid and quantitative detection of blood glucose in vivo are realized. The hydrogel microneedle patch contains two hydrogel components: one hydrogel component is hydrogel which can be cured and formed by ultraviolet light, and the other hydrogel component is hydrogel which can be cured and formed by ultraviolet light; and the other hydrogel is functional hydrogel with pH responsiveness, and glucose oxidase is added, so that the hydrogel can sensitively react to in-vivo glucose. The double-response hydrogel is jointly mixed and prepared into a microneedle patch form, the microneedle patch is endowed with noninvasive/minimally invasive property when applied to the skin surface, the microneedle patch is very suitable for extraction of interstitial fluid in vivo, and then real-time, rapid and accurate detection of the blood glucose level in vivo is achieved.

Description

technical field [0001] The invention belongs to the field of biomedical research, and in particular relates to a hydrogel microneedle patch for non-invasive blood glucose detection and a preparation method and application thereof. Background technique [0002] Diabetes mellitus is a global chronic disease that seriously threatens human health and life safety, and its typical feature is hyperglycemia. The World Health Organization reports that in 2017, there were approximately 425 million adults with diabetes worldwide, and the number is expected to continue to increase as the population ages and changes in lifestyle. If the blood sugar level is not well controlled, it will cause various complications in diabetic patients, such as amputation, blindness, cardiovascular and kidney diseases, and even death. Regular blood sugar monitoring for people with diabetes can better control blood sugar and prevent complications. [0003] The blood glucose monitoring products on the mark...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/145A61B5/1486A61B5/00
CPCA61B5/14532A61B5/14865A61B5/1486A61B5/685A61B2503/40A61B2503/42
Inventor 雷祎凤王燕薛龙建刘海洋杨旭霞李静雯
Owner WUHAN UNIV
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