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Antimicrobial dressing capable of being dissolved as required and preparation method thereof

A solution and surface modification technology, applied in medical science, bandages, etc., can solve problems such as poor biocompatibility, lack of antibacterial properties, and increased wound size, achieve excellent physical, chemical and biological properties, avoid secondary damage, The effect of good biocompatibility

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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, conventional cutting or mechanical removal of the dressing may result in stripping of the new epidermis, further increasing wound size and ultimately delaying wound healing
Most traditional dressings lack antibacterial properties, or have unstable antibacterial properties and poor biocompatibility

Method used

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  • Antimicrobial dressing capable of being dissolved as required and preparation method thereof
  • Antimicrobial dressing capable of being dissolved as required and preparation method thereof
  • Antimicrobial dressing capable of being dissolved as required and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0035] The preparation method of above-mentioned antibacterial dressing, comprises the steps:

[0036] 1) Add chitosan to a solution containing acetic acid and water, reflux at 40°C for 0.5-2h, add polyethylene glycol diacrylate, continue refluxing at 40°C for 12-48h, wash with water and alcohol, A highly transparent pale yellow prepolymer solution is obtained; the mass ratio of chitosan, acetic acid, polyethylene glycol diacrylate and water is 0.5-2:0.5-2:10-30:100.

[0037] 2) Weigh the surface-modified zinc oxide powder, and the particle size of the zinc oxide powder is 30-100 nm. Prepare a zinc oxide suspension with a mass fraction of 20%, and drop the suspension into the prepolymer solution obtained in step 1) to obtain a semi-solid gel product;

[0038] 3) placing the obtained semi-solid gel-like product in a dilute acetic acid solution, and the semi-solid gel-like product is dissolved within 1-2 minutes, and has good dissolving performance on demand.

[0039] Specific...

Embodiment 1

[0041] 1) Add 1 part of chitosan to a solution containing 1 part of acetic acid and 100 parts of water, reflux at 40 °C for 1 hour, add 20 parts of polyethylene glycol diacrylate, continue to reflux at 40 °C for 24 hours, wash with water and alcohol , a highly transparent pale yellow prepolymer solution was obtained.

[0042] 2) Weigh the surface-modified zinc oxide powder with a particle size of 30 nm, prepare a zinc oxide suspension with a mass fraction of 20%, drop the suspension into the above solution, and wait for a few seconds to obtain a semi-solid gel product.

[0043] 3) The gelatinous product is placed in a dilute acetic acid solution, and the gel is dissolved within 1-2min, indicating that the product has good solubility on demand.

Embodiment 2

[0045] Take the gel-like product prepared in Example 1 as a sample, and carry out relevant performance tests:

[0046] figure 1 It is a scanning electron microscope image of the product formed by the action of zinc oxide solution (particle size of 30nm) and prepolymer. It can be seen from the figure that the product presents a three-dimensional network porous structure with a pore size of about 2.0um. The developed porous structure gives the product excellent quality. It has good application prospects in the fields of dressings and the like.

[0047] figure 2 The scanning electron microscope image of the product after adding a few drops of dilute acetic acid shows that the three-dimensional network structure has been destroyed, and most of the product has been degraded, indicating that the product has on-demand solubility.

[0048] image 3 Optical photograph of degradation of a gel-like product.

[0049] Figure 4 For the antibacterial effect of the product on Escherichia...

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Abstract

The invention belongs to the technical field of antibacterial materials, and particularly relates to an antibacterial dressing capable of being dissolved as required, which is a gel formed by physically blending a first component and a second component, the first component is a prepolymer synthesized from a polyethylene glycol derivative with an unsaturated group at the end part and chitosan through a grafting reaction; the second component is surface-modified nano zinc oxide, and the second component is used as an antibacterial agent and a cross-linking agent of the antibacterial dressing. The polyethylene glycol derivative has excellent physicochemical and biological characteristics, the synthesized chitosan / polyethylene glycol copolymer has unique advantages in treatment of deep burn and orthopedic injury, and the nano zinc oxide inorganic antibacterial agent is coupled to construct the chitosan / polyethylene glycol copolymer which is good in stability and good in biocompatibility. The zinc oxide / chitosan / polyethylene glycol-based composite antibacterial dressing has the advantages of good antibacterial property, good biocompatibility, and realization of on-demand dissolution of the dressing by adjusting the external pH and ionic strength, thereby avoiding secondary damage caused in the dressing removal process.

Description

technical field [0001] The invention belongs to the technical field of antibacterial materials, and in particular relates to an antibacterial dressing that can be dissolved on demand and a preparation method thereof. Background technique [0002] A dressing, or wound dressing, is a material used to wrap a wound, covering a sore, wound, or other damage. Traditional dressings are mainly dry gauze and oil gauze, while modern wound dressings cover a wider range and have more types. The usual types are: 1. Passive dressings (traditional dressings) passively cover the wound surface and absorb exudates. Wounds provide limited protection; 2. Interactive dressings, there are various forms of interaction between dressings and wounds, such as absorbing exudates and toxic substances, allowing gas exchange, thereby creating an ideal environment for healing; Barrier outer layer structure to prevent the invasion of microorganisms in the environment, to prevent cross infection of wounds, e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
CPCA61L26/0023A61L26/0019A61L26/0004A61L26/0066A61L2300/404A61L2300/232A61L2300/102C08L71/02C08L5/08Y02A50/30
Inventor 冯健辉张辉张瑾成富刘盛全
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