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Biomaterials for bone tissue engineering

A technology of biomaterials and tissues, applied in the direction of bone implants, applications, skulls, etc., can solve problems such as difficult functional biomaterials

Pending Publication Date: 2022-08-05
SPIDERWORT INC +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these polymers, whether natural or synthetic, may show some potential in BTE, extensive, difficult and / or expensive protocols are used to obtain functional biomaterials and / or macrostructures, and each Each has its own limitations

Method used

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  • Biomaterials for bone tissue engineering
  • Biomaterials for bone tissue engineering
  • Biomaterials for bone tissue engineering

Examples

Experimental program
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Effect test

Embodiment 1

[0295] Example 1 - Plant-Derived Biomaterials for Bone Tissue Engineering - Biomechanical Characterization of Cellulose Scaffolds for In Vivo and In Vitro Bone Tissue Engineering

[0296] Natural macroscopic cellulose structures can be derived from a variety of plants. It has been demonstrated that plant-derived cellulose-based scaffolds treated with surfactants can be used as materials for various tissue reconstructions by utilizing the natural structure of plants [14]. These biomaterials can be used in in vitro mammalian cell culture [14] and are biocompatible and spontaneously vascularized subcutaneously [14]–[16]. Biomaterials can be derived from specific plants depending on the intended application [14]–[18]. For example, the vascular structures of plant stems and leaves display vascular structures similar to those found in animal tissues [18]. Plant-derived cellulose scaffolds can also be easily sculpted into specific shapes and treated to alter their surface biochemic...

Embodiment 2

[0351] Example 2 - Plant-derived biomaterial pre-coated with apatite (pre-mineralized) for bone tissue engineering

[0352] Custom three-dimensional scaffolds, matrices, grafts and / or artificial tissues for bone tissue engineering applications are desirable. To construct this material, natural sources (ie plants) are decellularized and features of interest are extracted (porous structure, micro and macro channels, semipermeable membranes) and subsequently pre-coated with alternating calcium chloride and disodium phosphate solutions .

[0353] When bone tissue is severely damaged by trauma or various diseases, a graft or bone substitute may be required. This bone graft promotes active bone formation. It can be implanted to repair critical and / or non-critical size defects. This bone graft can provide mechanical support during bone repair. For example, such implants can be used to replace loss or damage to long bones, cranial bones, maxillofacial bones, teeth and / or jaws. Su...

Embodiment 3

[0358] Example 3 - Composite Biomaterials

[0359] In these studies, the development of composite biomaterials was sought, combining two or more scaffold biomaterials and / or grafts described herein, thereby providing further advantages to the scaffold biomaterials and / or grafts described herein Adjustability. As can be appreciated, such composite biomaterials are desirable not only in the BTE applications described herein, but also in a variety of other applications where scaffold biomaterials may be used and require tunability of scaffold structure and / or chemistry feasible.

[0360] In this study, different biomaterial subunits were combined by gluing. Although there may be many glues, this study used gelatin cross-linked with glutaraldehyde glue (reduced with sodium borohydride). First, carve the starting material into the desired shape. The desired shape is then removed from the bulk material by slicing on a mandolin slicer. The thickness of the mandolin slice sets th...

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Abstract

Provided herein are scaffold biomaterials comprising a decellularized plant or fungal tissue from which cellular material and nucleic acid of the tissue are removed, the decellularized plant or fungal tissue having a 3-dimensional porous structure; wherein the decellularized plant or fungal tissue may optionally be at least partially coated or mineralized, and wherein the scaffold biomaterial may optionally further comprise a protein-based hydrogel and / or a polysaccharide-based hydrogel, or both. Also provided herein are methods and uses of such scaffold biomaterials, e.g., including methods of manufacture and methods and uses for bone tissue engineering.

Description

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS [0002] This application claims priority to US Provisional Patent Application 62 / 950,544, filed December 19, 2019, entitled "Biomaterials for Bone Tissue Engineering," the contents of which are incorporated herein by reference in their entirety. technical field [0003] The present invention generally relates to scaffold biomaterials. More specifically, the present invention relates to scaffold biomaterials for bone tissue engineering comprising decellularized plant or fungal tissue. Background technique [0004] Large bone defects caused by injury or disease often require biomaterial grafts for complete regeneration [1]. Typically, techniques aimed at enhancing bone tissue regeneration employ autologous, allogeneic, xenogeneic or synthetic grafts [2]. Autologous bone grafting, in which the material is derived from the patient, is considered the "gold standard" grafting practice in the repair of large bone defects, but suffe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/52A61F2/28A61F2/30
CPCA61L27/52A61F2/28A61F2/2803A61F2/2875A61F2002/2835A61F2002/2839A61F2002/2889A61F2/30942A61F2002/30677A61F2002/3092A61F2002/30948A61F2/3094A61F2310/00976A61F2310/00982A61L27/54A61L27/56A61L27/58A61L27/46A61L27/38A61L27/20A61L2430/02A61L27/3637A61L27/3683C08L5/08A61L27/047A61L27/10A61L27/12A61L27/24A61L27/3691A61L27/3821A61L2400/12A61L2430/12A61L2430/40
Inventor M·勒布朗·拉图尔R·希基C·M·柯里尔A·E·佩林M·塔拉尔I·卡特拉
Owner SPIDERWORT INC
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