Construction method of Bestrophin3 vascular smooth muscle specific gene knockout mouse and aortic dissection mouse model
A gene knockout mouse, vascular smooth muscle technology, applied in the fields of botany equipment and methods, biochemical equipment and methods, genetic engineering, etc., can solve the problem of large experimental loss, high mortality rate, and low molding rate of knockout mice and other problems, to achieve the effect of simple modeling and high morbidity
Pending Publication Date: 2022-08-09
SUN YAT SEN UNIV
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The invention discloses a construction method of Bestrophi n3 vascular smooth muscle specific gene knockout mouse and aortic dissection mouse models, and relates to the field of mouse model establishment. The aortic dissection mouse model is constructed by the following steps: adopting a Bestphi n3 vascular smooth muscle specific gene knockout mouse, called Best3SMKO mouse for short, and feeding the Best3SMKO mouse for 24 weeks to spontaneously form aortic dissection or aortic aneurysm. According to the application, aortic dissection can be induced by deletion of Bestrophi n3 in vascular smooth muscle cells, the constructed Bestrophi n3 smooth muscle specific knockout mouse is an aortic dissection/aneurysm mouse model which is high in morbidity, similar to the human aortic dissection morbidity in age and high in quality, the AD morbidity of the Best3SMKO mouse reaches 63%, the morbidity is high, and modeling is simple.
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