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Gongxuening capsule quality determining method

A method of determination, the technology of Gongxuening, is applied in the field of determination of the main active ingredients of Gongxuening Capsules, which can solve the problems of cumbersome testing and many interference factors, and achieve the effects of controlling product quality, enhancing physiological activity, and solving technical problems

Inactive Publication Date: 2004-09-15
YUNNAN BAIYAO GROUP
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Problems solved by technology

However, the quality standard of the original product has been using the biological test method, that is, the rat uterine contraction test, the test is cumbersome, there are many interference factors, and the concept of infinity is far from meeting the actual needs of production.

Method used

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  • Gongxuening capsule quality determining method
  • Gongxuening capsule quality determining method
  • Gongxuening capsule quality determining method

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Embodiment Construction

[0015] (1) Instruments and reagents: HPLC, Waters M510 pump, 717 autosampler, PDA detector, TCM column temperature control system, 2010 workstation; analytical pure methanol, chromatographically pure acetonitrile, Kunming Plant, Chinese Academy of Sciences The saponin VI reference substance provided by the institute.

[0016] (2) Chromatographic conditions: column Symmetry C 8 4.6×250mm; mobile phase is acetonitrile-water (45:55); detection wavelength is 203nm; column temperature is 40°C; flow rate is 1ml / min. Under this condition, the saponins VI and other components can reach the baseline separation, as attached figure 1 shown.

[0017] (3) Preparation of the reference substance solution: Accurately weigh an appropriate amount of the pachyphyllin saponin VI reference substance, add methanol to make a solution containing 0.4 mg per 1 ml, and use it as the reference substance solution.

[0018] (4) Preparation of the test solution: methanol was used to extract the steroida...

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Abstract

The present invention relates to the analysis of effective medicine components. The determination of Gonxuening capsule quality includes setting precisely weight 1 gram of Gonxuening capsule medicine and 25 ml of methane into one cone flask and sealing closely; weighting; supersonic treatment at 250 W powder and 25 KHz frequency for 40 min; cooling, weighting and replenishing the weight loss with methane; shaking, filtering and taking the secondary filtrate as tested sample solution; and determining in liuqid phase chromatographic instrument with 10 microgram of tested sample solution and 10 microgram of reference solution. The qualified product should have one Chinese paris saponin content not less than 0.4 %.

Description

Technical field [0001] The invention relates to a drug analysis and determination method. More specifically, the present invention relates to a method for determining the main active ingredients of Gongxuening Capsules. Background technique [0002] Gongxuening Capsules are capsules made from the extracts of Liliaceae Eurythia yunnanensis or Aesculus chinensis. It has the functions of cooling blood to stop bleeding, clearing heat and dehumidification, removing blood stasis and relieving pain. It is used for metrorrhagia, menorrhagia, postpartum or post-abortion uterine contraction bleeding and functional uterine bleeding with blood-heat syndrome. As well as lower abdominal pain, lumbosacral pain, and increased vaginal discharge caused by damp-heat stasis of chronic pelvic inflammatory disease. Due to its remarkable curative effect, it is welcomed by the majority of patients and has been listed as a national essential drug by the Ministry of Health. However, the quality s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/15
Inventor 韦建荣赵永言高崇昆赵守仁
Owner YUNNAN BAIYAO GROUP
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