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Cosmetics composition containing aminophenol derivatives and isoflavone like substance

A kind of aminophenol, technology of composition, applied in the field of composition

Inactive Publication Date: 2005-06-15
LOREAL SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, to the best of the applicant's knowledge, there is no technology for combining isoflavones with aminophenol derivatives

Method used

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  • Cosmetics composition containing aminophenol derivatives and isoflavone like substance
  • Cosmetics composition containing aminophenol derivatives and isoflavone like substance

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Example 1: Demonstration of the synergistic effect of the compounds of the invention

[0062] In vitro biological tests (inhibition of fungal tyrosinase) demonstrate the depigmentation activity of the combined application of the compounds of the present invention.

[0063] The test consists in the determination of the absorbance (optical density OD) at a wavelength of 475 nm as a function of time for each active depigmenting agent to be tested.

[0064] Dissolve these reagents (at various concentrations) in a suitable solvent containing phosphate buffered saline, 1 ml of 2.0 x 10 -3 M L-tyrosine in phosphate buffered saline, 0.1 ml 1.0 x 10 -4 The phosphate buffered saline solution of L-dopa of M and the phosphate buffered saline solution of fungal tyrosinase of 1g / L concentration in 50 microliters, the reference substance is made up of the solvent containing the phosphate buffered saline solution of the same concentration. Calculate percent inhibition by the followin...

Embodiment 2

[0079] Example 2: Oleosome-type O / W fluid

[0080] Prepare the following compositions, and the weight percentages of each composition are as follows

[0081] Phase A

[0082] N-ethoxycarbonyl-4-aminophenol 0.5%

[0083] Stearyl Enanthate and Stearyl Caprylate 5.5%

[0084] Vegetable oil 11.6%

[0085]UVA masking agent 1.9%

[0086] Cyclopentasiloxane 3.7%

[0087] Sucrose Tristearate 2.0%

[0088] Oxyethylated (4EO) sorbitan monostearate 1.35%

[0089] Stearic acid 1.0%

[0090] Oxyethylated (60EO) Hydrogenated Castor Oil 2.5%

[0091] Tocopheryl acetate 0.5%

[0092] Phase B

[0093] Fujiflavone P40 (Maruzen) 0.1%

[0094] Preservatives 0.29%

[0095] Triethanolamine 0.50%

[0096] Disodium EDTA 0.05%

[0097] Glycerin 3.0%

[0098] Add water to 100.0%

[0099] Get a bleaching fluid for your face.

[0100] It can be obtained by heating phase A and phase B separately to 65°C and then cooling them to room temperature. Then add phase B into phase A to obtain a ...

Embodiment 3

[0101] Example 3: Grease body-type O / W fluid

[0102] Prepare the following compositions, and the weight percentages of each composition are as follows

[0103] Phase A

[0104] N-ethoxycarbonyl-4-aminophenol 0.5%

[0105] Stearyl Enanthate and Stearyl Caprylate 5.5%

[0106] Vegetable oil 11.6%

[0107] UVA masking agent 1.9%

[0108] Cyclopentasiloxane 3.7%

[0109] Sucrose Tristearate 2.0%

[0110] Oxyethylated (4EO) sorbitan monostearate 1.35%

[0111] Stearic acid 1.0%

[0112] Oxyethylated (60EO) Hydrogenated Castor Oil 2.5%

[0113] Tocopheryl acetate 0.5%

[0114] Phase B

[0115] Flavosterone SB (Ichimaru Pharcos) 10.0%

[0116] Preservatives 0.29%

[0117] Triethanolamine 0.50%

[0118] Disodium EDTA 0.05%

[0119] Glycerin 3.0%

[0120] Add water to 100.0%

[0121] The bleaching fluid for the face can be obtained in the same manner as in Example 2.

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PUM

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Abstract

The present invention relates to a composition comprising at least one aminophenol derivative and at least one isoflavone in a physiologically acceptable medium. The invention also relates to the use of the composition in the preparation of a preparation for depigmentation and / or bleaching of human skin. These combinations of active ingredients show a synergistic effect in depigmentation or bleaching of the skin.

Description

technical field [0001] The present invention relates to a composition comprising at least one aminophenol derivative and at least one isoflavonoid in a physiologically acceptable medium; Use in cosmetic and / or dermatological preparations for depigmentation and / or bleaching of human skin. Background technique [0002] Over the years, many attempts have been made to come up with harmless highly effective topical depigmenting substances. Most particularly needed are these highly potent substances for the treatment of: Regional hyperactivity of melanocytes (e.g. idiopathic melasma, during pregnancy ("gravid spots" or melasma) or during estrogen-progestin contraception) Hyperpigmentation, localized hyperpigmentation due to benign melanocytic hyperplasia and hyperactivity (eg, age spots known as actinic lentigo, sporadic hyperpigmentation, or depigmentation, which may result from photosensitization or post-lesional scarring), and certain leukoplakia diseases, such as vitiligo. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K7/48A61K8/30A61K8/00A61K8/02A61K8/06A61K8/41A61K8/42A61K8/46A61K8/49A61Q17/04A61Q19/00A61Q19/02
CPCA61K8/411A61K8/415A61K8/498A61Q19/02A61K8/42A61K8/49
Inventor V·舍瓦利耶D·-M·法姆
Owner LOREAL SA