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Method for picking-up general flavone from hawthorn fruit by using microwave

An extraction method and a technology of total flavonoids, which are applied in pharmaceutical formulas, medical preparations containing active ingredients, organic chemistry, etc., can solve problems such as low efficiency and long time required for enzymatic hydrolysis, and achieve low temperature, low cost, and improved The effect of utilization

Inactive Publication Date: 2005-06-15
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

However, enzymatic hydrolysis takes a long time and the efficiency is relatively low

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0006] Embodiment 1: Get the fresh hawthorn fruit, wash it, remove the seeds and slice it, put it into a drying box and dry it for 4 hours. Select hawthorn powdery granules, weigh 10g, add 100ml of 70% medicinal ethanol, soak for 25 minutes, and put it into a microwave oven. The microwave power density is adjusted to 60W / g, and the irradiation time is 56 seconds for microwave irradiation to ensure that the temperature of the ethanol aqueous solution is below the boiling point. It was then cooled in an ice-water bath, and the irradiation was repeated 12 times. Ethanol is recovered by filtration under reduced pressure to obtain leachate, which is passed through a macroporous adsorption resin column, washed with distilled water, and then eluted with 80% medicinal ethanol to obtain an ethanol solution of the total flavonoid preparation. The ethanol is recovered, the concentrated solution is poured into a container and heated to dryness in a water bath to obtain the total flavonoi...

Embodiment 2

[0007] Embodiment 2: The technological process is basically the same as that of Embodiment 1, except that the microwave irradiation time is 1 minute, and the irradiation is repeated 5 times.

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PUM

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Abstract

The invention relates to an extraction method of traditional Chinese medicine, namely microwave extraction of total flavonoids of hawthorn. The hawthorn fruit is deseeded, sliced, dried and crushed into different particle sizes, soaked in ethanol aqueous solution, and then processed by microwave. The microwave irradiation power is controlled to 40-70W / g, the irradiation time is 30-60 seconds, the temperature of the ethanol aqueous solution is below the boiling point, and then cooled with ice water and repeated 3-15 times. The advantages of the present invention are: (1) using ethanol aqueous solution as the extractant, adopting microwave heating to promote the extraction of active ingredients, combined with macroporous adsorption resin for separation, and overcoming the disadvantages of easy coagulation and coking of hawthorn fine powder during extraction by traditional methods. (2) The extractant is pollution-free, does not boil during the extraction process, has short extraction time, and has high purity of target components. The invention starts from the application of microwave technology to transform the traditional process, so there is no special requirement on the existing equipment, less process changes, simple and reliable process, and is suitable for industrial production.

Description

technical field [0001] The invention relates to a method for extracting traditional Chinese medicines, more precisely, a method for extracting total flavonoids of hawthorn. Background technique [0002] Hawthorn is commonly used in Chinese patent medicines because it has many functions such as promoting digestion, invigorating stomach, promoting qi and dispelling silt, etc. In recent years, studies have found that hawthorn has many new pharmacological effects. The active ingredient total flavonoids extracted from hawthorn pulp has pharmacological effects such as lowering blood pressure and blood fat, increasing coronary flow, strengthening the heart, and antiarrhythmia. Traditional methods for extracting total flavonoids include water decoction, ethanol reflux extraction, and Soxhlet method. These methods all have problems such as long extraction time, high dissolution rate of impurities, large amount of solvent used, low extraction efficiency, an...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D311/30
Inventor 郭锦棠杨俊红孙永利赵沧燕
Owner TIANJIN UNIV