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Eye gel for atropine sulfate

A technology of atropine sulfate and ophthalmic gel, which is applied in the fields of pharmaceutical formulations, sensory diseases, active ingredients of heterocyclic compounds, etc. It can solve problems such as short residence time, eye drops are easily diluted by tears, and oral drugs are difficult to pass through the blood-ocular barrier. , to achieve long residence time, avoid other side effects, and avoid gastrointestinal irritation

Inactive Publication Date: 2005-06-22
SHENYANG XINGQI PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In order to overcome the large amount of administration and the difficulty of oral drugs passing through the blood-ocular barrier, an ophthalmic gel was invented for topical administration in ophthalmology. Small amount, improve the bioavailability of the active ingredients of the drug, increase the curative effect and drug safety

Method used

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  • Eye gel for atropine sulfate
  • Eye gel for atropine sulfate

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Embodiment Construction

[0008] Prescription 1:

[0009] Atropine Sulfate 1.0g

[0010] Hypromellose 4.0g

[0011] Borax 1.0 g

[0012] Boric acid 0.5g

[0013] Chlorinated benzalkonium 0.01 g

[0014] Water for injection made 100g

[0015] Operation process:

[0016] ①. Take the prescribed amount of hypromellose and swell with an appropriate amount of water for injection, overnight.

[0017] ②. Take the prescribed amount of borax and boric acid and add it, stir evenly, and heat to form a transparent gel matrix;

[0018] ③. Add benzalkonium chloride and stir to dissolve;

[0019] ④. Add atropine sulfate, add water to the full amount, and stir well;

[0020] ⑤. Filter through a 220-mesh sieve cloth, autoclave, and pack.

[0021] Prescription 2:

[0022] Atropine sulfate 0.1-5.0g

[0023] Hypromellose 0.1-20.0g

[0024] Borax 0.1-5.0g

[0025] Boric acid 0.1-2.5 grams

[0026] Chlorinated benzalkonamine 0.01-0.5 g

[0027] water for injection made 100g

[0028] Operation process:

[002...

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Abstract

The present invention relates to an ophthalmic gel prepared for the first time as an active ingredient of a drug, atropine sulfate, which can selectively block M-cholinergic receptors and resist the M-receptors of acetylcholine and its cholinergic drugs. Body stimulant, can contact smooth muscle spasm, can simulate glandular secretion, dilate pupil. In the present invention, atropine sulfate is made into ophthalmic gel for the first time, which not only solves the problem that eye drops are easily diluted by tears and the residence time in the eye is short; moreover, it improves the bioavailability of the active ingredients of the medicine, increases the curative effect and the safety of medication. The main technical content is: atropine sulfate, hydroxypropyl methylcellulose, boric acid, borax, and chlorinated benzalkamine to make a stable water-soluble transparent cream body, which forms a layer of breathable mesh film on the eye surface after use. It has a long-lasting effect and is mainly used for fundus examination and dilation before optometry, mydriasis before eye surgery, and postoperative adhesion prevention. It can also be used for the treatment of keratitis, iridocyclitis, etc.

Description

Technical field [0001] The invention relates to an active ingredient of a medicine - atropine sulfate - which is made into ophthalmic gel for the first time, and is applied to dilate mydriasis before eye surgery and prevent adhesion after operation. It can also be used for the treatment of keratitis, iridocyclitis, etc. Background technique [0002] In addition to using tablets and injections in domestic clinical practice, 1.0% ophthalmic ointment (based on Vaseline) is often used in ophthalmic preparations; in addition to 1.0% ophthalmic ointment, 1.0% atropine sulfate eye drops are also used in foreign ophthalmic medicines. The development and use of atropine sulfate ophthalmic gel have not been reported, and there are people who use gels (non-ophthalmic) in the hospital preparations of domestic medical institutions. According to reports, the effect is very good. Atropine sulfate ophthalmic gel has not yet seen the report of research and production. Contents of the inve...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/46A61P27/02
Inventor 刘继东姚东民高峨宋长海
Owner SHENYANG XINGQI PHARM CO LTD
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