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Preparation of medicine for treating male's sterility

A technology for male infertility and drugs, which is applied in the direction of drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve the problems of large amount of excipients, loss of volatile components, and large side effects, etc., to reduce the amount of excipients, The effect of improving utilization rate and improving stability

Inactive Publication Date: 2005-07-27
NANJING ZHONGSHAN PHARMA CO LTD
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  • Abstract
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  • Application Information

AI Technical Summary

Problems solved by technology

[0002] According to market research, about 10%-15% of married couples of childbearing age in my country suffer from infertility (pregnancy), of which about 25% are immune infertility (pregnancy), and the current treatment of immune infertility (pregnancy) Western medicine is mainly glucocorticoids, but because of its large side effects and the disadvantages that adverse reactions are difficult to control, its application is greatly limited
There are also many formulas in traditional Chinese medicine, most of which are traditional water decoction, the active ingredients are not fully extracted, and the efficacy of the medicine cannot be well exerted; such as the Chinese medicine for the treatment of immune infertility and infertility in patent number: 99120678.9, its raw materials are mainly Including Epimedium, Ligustrum lucidum, Cistanche, Cnidium, Yizhiren, Angelica, Lycium barbarum, Schisandra, peach kernel, licorice and other traditional Chinese medicines, but because the optimal preparation method has not been further studied, only mixed decoction is used. Although its decoction has a certain curative effect, after all, many active ingredients are incompletely extracted, the volatile ingredients are almost completely lost, and the fat-soluble active ingredients are also difficult to dissolve in water, which greatly reduces the expected therapeutic effect of the medicine. Adapt to the requirements of industrialized mass production
Even after being boiled in water and extracted with alcohol, mixed with excipients, concentrated, dried and made into tablet traditional Chinese medicine, its volatile components such as Yizhiren and Cnidium volatile oil and Angelica volatile components are almost completely lost, and the amount of excipients is large , resulting in too much dosage, even exceeding 4 grams per time, the effect still cannot reach the expected therapeutic effect of the drug

Method used

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Embodiment Construction

[0015] The present invention is further described and illustrated as follows:

[0016] The medicine of the present invention comprises 8-10% of traditional Chinese medicine Epimedium, Ligustrum lucidum 8-10%, Cistanche 8-10%, Cnidium 8-10%, Yizhiren 10-15%, Angelica 10-10% by weight percentage. 13%, medlar 8-10%, schisandra 8-10%, peach kernel 12-15%, licorice 10-15%, the following steps can be taken to extract the effective active ingredients of raw materials in the above ratio range.

[0017] A) Weigh each raw material Epimedium Herba, Ligustrum lucidum, Cistanche, Cnidium Fructus Cnidii, Yizhiren, Angelica, Lycium barbarum, Schisandra chinensis, peach kernel, licorice, and set aside by weight;

[0018] B) Distillation and extraction: steam distilling and extracting the volatile oil from the Yizhiren in the weight ratio; extracting the volatile oil from the Angelica sinensis in the weight ratio by supercritical extraction with carbon dioxide;

[0019] C) Inclusion: Weigh an...

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Abstract

The medicine for treating male's sterility is compounded with the effective components extracted from epimedium, privet fruit, desert cistanche, cnidium fruit, galangal fruit and other five kinds of Chinese medicinal materials. The preparation process includes the steps of: weighing the medicine materials; distillation and extraction; wrapping; concentration; crushing; mixing and drying to obtain the effective components; mixing with supplementary material; and pelletizing or tablet pressing. The medicine of the present invention has the functions of invigorating kidney, strengthening Yang, nourishing Yin, nourishing blood, promoting blood circulation to disperse blood clots, etc.; has obvious male's sterility treating effect; and may be produced in industrial scale.

Description

Technical field: [0001] The invention relates to a preparation method of a traditional Chinese medicine, in particular to a preparation method of a traditional Chinese medicine capable of treating male infertility, and belongs to the field of medical preparations. Background technique: [0002] According to market research, about 10%-15% of married couples of childbearing age in my country suffer from infertility (pregnancy), of which about 25% are immune infertility (pregnancy), and the current treatment of immune infertility (pregnancy) Western medicine is mainly glucocorticoid, but because of its large side effects and the disadvantages that adverse reactions are difficult to control, its application is greatly limited. There are also many formulas in traditional Chinese medicine, most of which are traditional water decoction, the active ingredients are not fully extracted, and the efficacy of the medicine cannot be well exerted; such as the Chinese medicine for the treatm...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61P15/08
Inventor 王志华濮存海陈彬辉高金花丁勇
Owner NANJING ZHONGSHAN PHARMA CO LTD