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Implanted degradable high molecular material medicine control-release carrier and its preparing process

A polymer material and drug controlled release technology, applied in the field of implantable degradable polymer material drug controlled release carrier, can solve the problems of patient inconvenience, increased clinical use, and increased use cost

Inactive Publication Date: 2005-10-19
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these two types of micro-drug delivery systems based on MEMS technology have different working principles, they have a common shortcoming, that is, after the filled drug is released, the implanted drug delivery system must be removed by surgery.
This increases the cost of use and increases the difficulty of clinical use, especially bringing more inconvenience and pain to patients.

Method used

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  • Implanted degradable high molecular material medicine control-release carrier and its preparing process
  • Implanted degradable high molecular material medicine control-release carrier and its preparing process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Example 1, see figure 1 Firstly, a layer of sacrificial layer 2 is coated on the substrate 1, and a layer of SU-8 photoresist 3 with a thickness of 600 μm is evenly coated on the sacrificial layer 2, and then dried, and the photoresist 3 is processed through the mask plate 4 Exposure to deep ultraviolet light lithography, said mask 4 is a microarray structure with through holes, and the aperture of the through holes is 500 μm; develop in a developer to obtain a mold 5 with a microarray structure , the hole depth of the mold 5 is 600 μm, and the pore diameter is 500 μm; the polydimethylsiloxane is coated on the mold 5, and the thickness of the coating is 700 μm; the controlled release carrier mold 6 is obtained after demoulding from the mold 5; The degradable polymer material polylactic acid polyglycolic acid is coated on the controlled release carrier mold 6, and the coating thickness is 700 μm, see figure 2 After the plastic molding, an implantable degradable polymer...

Embodiment 2

[0011] Example 2, first coat a layer of sacrificial layer 2 on the substrate 1, uniformly coat a layer of SU-8 photoresist 3 with a thickness of 300 μm on the sacrificial layer 2, and then dry it. Glue 3 is exposed to deep ultraviolet light lithography, and said mask plate 4 is a microarray structure with a through hole, and the aperture of the through hole is 50 μm; it is developed in a developer to obtain a microarray structure with a microarray structure. mold 5, the hole depth of the mold 5 is 300 μm, and the hole diameter is 50 μm; polymethyl methacrylate is coated on the mold 5, and the thickness of the coating is 360 μm; the controlled release carrier mold 6 is obtained after demoulding from the mold 5 ;Coat the degradable polymer material polylactic acid on the controlled release carrier mold 6, the thickness of the coating is 360μm, and after the mold, an implantable degradable polymer material drug controlled release with a microarray structure with grooves is obtaine...

Embodiment 3

[0012] Example 3, first coat a layer of sacrificial layer 2 on the substrate 1, uniformly coat a layer of SU-8 photoresist 3 with a thickness of 50 μm on the sacrificial layer 2, and then dry it. Glue 3 is exposed to deep ultraviolet light lithography, and said mask plate 4 is a microarray structure with through holes, and the aperture of the through holes is 280 μm; it is developed in a developer to obtain a microarray structure with a microarray structure. mold 5, the hole depth of the mold 5 is 50 μm, and the hole diameter is 280 μm; the polydimethylsiloxane is coated on the mold 5, and the thickness of the coating is 60 μm; the controlled release carrier mold is obtained after demoulding from the mold 5 6. Coat the degradable polymer material polyglycolic acid on the controlled-release carrier mold 6 with a coating thickness of 60 μm. After the mold is applied, an implantable degradable polymer material drug with a grooved microarray structure is obtained. For the controll...

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Abstract

Implantable degradable polymer material drug controlled release carrier and its preparation process, uniformly coat a layer of photoresist with a thickness of 50-600 μm on the sacrificial layer, pass through a mask with a microarray structure with 50-500 μm through holes The template exposes the photoresist to deep ultraviolet lithography to obtain a mold with a microarray structure with a hole depth of 50-600 μm and a pore diameter of 50-500 μm, and polydimethylsiloxane or polymethylmethacrylate Coating on the mold and demoulding to obtain the controlled-release carrier mold; coating the degradable polymer material on the controlled-release carrier mold, and after demoulding, a microarray structure with a width of 50-500 μm and a depth of 50-600 μm can be obtained. drug release carrier. The present invention uses the biodegradable material as the carrier of the implanted drug controlled release system. Under the action of biological enzymes, the carrier will be cracked layer by layer from the peripheral part. Drugs encapsulated in the microcavities are also gradually released.

Description

technical field [0001] The invention relates to an implantable degradable macromolecule drug controlled release carrier and a preparation process thereof. Background technique [0002] Microspheres and microcapsules: There are many types of this kind of sustained-release drug delivery system, and the production process also has a number of invention patents. Now, as the carrier form in drug delivery system, the most researched ones are still made into microparticles or even nanoparticles. It is small and can be injected with a common syringe during implantation, thereby avoiding surgical operations. Examples of the application of PLGA microparticles include: Lupron Depot, EnantoneDepot, Enantone Depot, Decapeptil, and Pariodel LA. At present, the latest research trends on polymer microcapsules mainly include the development of antigen-loaded nanoparticles and the development of pulsating release systems; non-degradable slow-release implant systems: after a certain period of ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/00A61K47/30G03F7/00
Inventor 陈天宁王万军陈花玲王小鹏皇甫勇崔战友
Owner XI AN JIAOTONG UNIV
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