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Combination of medicinal preparation of having antivirus function

An antiviral effect and composition technology, which can be used in antiviral agents, drug delivery, medical preparations containing active ingredients, etc., and can solve the problems of narrow antiviral scope, limited clinical application of antiviral drugs, and large drug toxicity and side effects.

Inactive Publication Date: 2005-11-23
成都厚发科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are many types of antiviral drugs, the clinical application of antiviral drugs has been greatly restricted due to their narrow antiviral scope, or because of the large toxic and side effects of drugs.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Composition: Zedoary oil for injection 50g

[0015] Coix Seed Oil for Injection 50g

[0016] Soybean Phospholipid for Injection 10g

[0017] Glycerin for injection 25ml

[0018] Add water for injection to 1000ml

[0019] Mix soybean phospholipids with preheated (80°C) water for injection and glycerin, stir in a high-speed tissue masher for 3 minutes at a speed of 8,000 rpm, and repeat three times to prepare a uniform phospholipid dispersion. After adding zedoary turmeric oil and coix seed oil preheated to 80°C, high-speed stirring is performed three more times under the same conditions to make the initial emulsion. After adding the same preheated water for injection to 1000ml, transfer it to the high-pressure milk homogenizer, at 3.089×10 4 kPa(315kg / cm 2 ) Under pressure, homogenize until the oil droplet size is about 1μm. After being filtered through a No. 4 vertical melting glass funnel, it is filled and sealed in a 10ml ampoule, filled with nit...

Embodiment 2

[0021] Take 120g of starch, 120g of lactose, 45g of dextrin, and 90g of low-substituted hydroxypropyl cellulose, respectively, and mix them evenly for use. Separately take 100g of turmeric oil and 50g of coix seed oil, add to the above auxiliary materials and mix well, then add 2.5% hypromellose to make granules, dry, add 9g sodium carboxymethyl starch and 4.5g magnesium stearate , And mix well again. Packing 1000 capsules into 1000 capsules, or compressing into 1000 capsules and coating them with a film, is the capsule or tablet.

Embodiment 3

[0023] Preheat 100 g of zedoary turmeric oil and 200 g of coix seed oil to 80° C., add them to the PEG-6000 melt, stir and mix, and prepare 5000 drops in a dropping pill machine, which is the pill-type medicine.

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PUM

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Abstract

The present invention is a pharmaceutical composition with antiviral effect, which is composed of zedoary oil and coix seed oil as effective medicinal ingredients, together with acceptable auxiliary additive ingredients in medicine, wherein the weight ratio of zedoary oil / coix seed oil is 1 / 0.5~1 / 4. The medicine can be made into various preparation forms such as oral form or spray form, nasal drop form or injection form with broad-spectrum antiviral effect. It can be preferentially used in the treatment of pediatric pneumonia, viral pneumonia, viral cold, acute upper respiratory infection, viral enteritis, viral myocarditis, encephalitis and other viral diseases. It is used in the treatment of lung cancer, liver cancer and It can also have the same significance and value in malignant tumors such as colon cancer.

Description

Technical field [0001] The present invention relates to a pharmaceutical composition with antiviral effect. Background technique [0002] Diseases caused by viruses are the main infectious diseases of mankind and seriously endanger human health. Although there are many types of antiviral drugs, the clinical application of antiviral drugs has been greatly restricted due to their narrow antiviral scope or the large side effects of drugs. [0003] Curcuma oil is a volatile oil extracted from the traditional Chinese medicine Curcuma. In vivo and in vitro tests have confirmed that it has obvious antiviral effects on influenza viruses A1, A3, and syncytial virus. It has a wide antiviral range and has no toxic side effects. Injection preparations are widely used in the treatment of pediatric pneumonia, viral pneumonia, acute upper respiratory tract infection, viral enteritis, viral myocarditis, encephalitis, etc. Summary of the invention [0004] The purpose of the present invention is...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K9/12A61P31/12
Inventor 杨秀清陈刚周家明
Owner 成都厚发科技开发有限公司
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