Phenasteroid gel preparation
A technology for finasteride and gel preparations, which is applied in the field of finasteride plastid gel preparations to achieve the effects of high encapsulation rate, improved drug efficacy, and changes in penetration performance
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Embodiment 3
[0033] Example 3 A preparation method of the present invention
[0034] Take 300 mg of soybean lecithin, 25 mg of finasteride, 3.8 ml of ethanol, and 6.8 ml of solvent, dissolve finasteride and soybean lecithin in ethanol, and inject buffer solution or water to 10 g in a trickle under airtight conditions at room temperature to obtain finasteride. For the steramine alcohol plastid suspension, the particle size of the alcohol plastid is controlled by probe type ultrasound (400-500w, 30-60 times), through a microporous filter membrane (0.1 micron or 0.22 micron), etc. to obtain finasteride alcohol For the finished plastid, the morphology of the finasteride alcohol plastid sample was observed by a transmission electron microscope. The particle size of the alcohol plastid was about 150 nm, and the appearance was regular circular or oval.
[0035] The finasteride alcohol plastid prepared by the above method is prepared into a gel. 45% low-molecular-weight alcohol and 0-3% antioxida...
Embodiment 4
[0037] Taking finasteride's water-saturated solution, 30% ethanol solution, and liposome as controls, the transdermal penetration properties of the aldol gel were studied. The human skin with the subcutaneous tissue removed was taken, washed with normal saline, and then fixed on a modified Franz diffusion cell. 20% PEG normal saline was used as the receiving solution, and an appropriate amount of previously prepared samples were added to the supply chamber and sealed. Samples were taken at the set time points, and an equal amount of fresh receiving solution was added. After 24 hours, the skin was removed, washed with water and dried, and the surface of the skin was wiped with alcohol cotton balls for several times. The epidermis and dermis of the skin were separated by hot plate method, mashed separately, and extracted with 30% methanol for 24 hours to determine the drug content. content. The results of the study showed that the finasteride plastid system was significantly be...
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Abstract
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