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Nano particles of poly-lactic acid or polyethyllactide propyllactide for packing plant extract

A technology of polyglycolide lactide and plant extracts, applied in the field of nanomedicine, can solve problems such as poor solubility, achieve delayed release, less loss, and improve absorption rate and bioavailability

Inactive Publication Date: 2006-08-02
HUNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the poor solubility of its main components such as fatty acids and lactones, and the resulting bioavailability problems have become more and more serious technical bottlenecks

Method used

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  • Nano particles of poly-lactic acid or polyethyllactide propyllactide for packing plant extract
  • Nano particles of poly-lactic acid or polyethyllactide propyllactide for packing plant extract
  • Nano particles of poly-lactic acid or polyethyllactide propyllactide for packing plant extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Weigh 30 mg of Maca and 150 mg of PLA and dissolve it in 2 ml of dichloromethane and ethanol mixed solution with a volume ratio of 5:1, add dropwise to 8 ml of 2.5% PVA aqueous solution with a mass percentage, and use a probe-type ultrasonic wave for 5 to 5 minutes in an ice bath. After 10 minutes, shake overnight in a shaker to remove dichloromethane and ethanol to obtain Maca-wrapped PLA nanoparticles with an average particle size of 250-350 nm.

Embodiment 2

[0028] Weigh 30 mg of maca and 150 mg of PLGA (L: G=50: 50, L: G is the mass ratio of lactic acid (Lactide) and glycolic acid (Glycolide) monomers in the copolymer polylactide glycolide) dissolved in a volume ratio of Add 2ml of 5:1 mixture of dichloromethane and ethanol dropwise into 8ml of 2.5% PVA aqueous solution by mass percentage, and use a probe-type ultrasonic wave for 5 to 10 minutes in an ice bath, place it in a shaker and vibrate overnight, remove Dichloromethane and ethanol were used to obtain Maca-wrapped PLGA nanoparticles with an average particle size of 250-350 nm.

Embodiment 3

[0030] Weigh 30 mg of Maca and 150 mg of PLGA (L: G=25: 75) and dissolve in 2 ml of dichloromethane and ethanol mixed solution with a volume ratio of 5: 1, add dropwise to 8 ml of 2.5% PVA aqueous solution in mass percentage, and place under ice bath Sonicate with a probe-type ultrasonic wave for 5-10 minutes, place in a shaker and vibrate overnight, remove dichloromethane and ethanol, and obtain PLGA nanoparticles wrapped with maca with an average particle size of 250-350 nm.

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Abstract

A polylactic PLA or poly-cyclic diester lactide PLGA nanometer particle for coating plant extract and its production are disclosed. PLA or PLGA nanometer particle is characterized by: coating plant extract as core matter with PLA or PLGA as shell membrane and forming nanometer spherical particle matter. The production is carried out by taking PLA or PLGA with good biological compatibility as carrier, taking polyvinyl alcohol PVA as emulsifier, and adopting solvent evolution method. Its advantages include low cost, simple process, to improve water soluble ability of main components, to improve plant extract adsorptive rate and biological utilizing rate.

Description

Technical field: [0001] The invention belongs to the field of nanomedicine, and in particular relates to wrapping various natural plant extracts to make polylactic acid (PLA) or polyglycolide lactide (PLGA) nanoparticles and a preparation method of the nanoparticles. Background technique: [0002] The plant extracts maca, kava, and ginger root oils are insoluble in water oils obtained by extracting the plant physiologically active components from maca root, kava root, and ginger root respectively. Maca can enhance physical strength, be energetic, eliminate anxiety, and improve sexual function. Kava is a good antidepressant with sedative-hypnotic, antifungal, antithrombotic, antifatigue, weight loss, and muscle relaxant effects. Ginger root oil has the effects of enhancing and strengthening blood circulation, stimulating the secretion of gastric juice, stimulating the intestinal tract, and promoting digestion. Recently, maca, kava, and ginger root oils frequently appear on ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/12C08L67/00B29B9/12A61K47/34
Inventor 王柯敏谭蔚泓郑明彬何晓晓吴萍彭姣凤
Owner HUNAN UNIV