Compound preparation containing rifampicin and isoniazid and its preparing method
A compound preparation and isoniazid technology are applied in directions such as medical preparations containing active ingredients, pharmaceutical formulations, organic active ingredients, etc., and can solve problems such as reduction of active ingredient content, impact on product quality, and no reports on production methods.
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Embodiment 1
[0033] (per 1000 pieces)
[0034] Inner Tablet Prescription:
[0035] Rifampicin 120g
[0036] Starch 10g
[0037] Hypromellose 8g
[0038] Cross-linked polyvinylpyrrolidone 4g
[0039] Povidone K 30 1.25g
[0041] Outer prescription:
[0042] Isoniazid 80g
[0043] Hypromellose 150g
[0044] Starch 100g
[0045] Cross-linked polyvinylpyrrolidone 3g
[0046] Povidone K 30 1.5g
[0048] Inner tablet film coating prescription:
[0049] Hydroxypropyl Methyl Cellulose 1.5g
[0050] Polyethylene glycol 6000 1.5g
[0051] 95% ethanol 72ml
[0052] Distilled water 8ml
[0053] Preparation Process
[0054] (1) Preparation of inner layer sheet:
[0055] Granulation: Pass the rifampicin main drug and auxiliary materials through 80 mesh sieve respectively, add the raw materials and auxiliary materials into a three-phase mixer, stir for several minutes to make them completely mixed eve...
Embodiment 2
[0062] (per 1000 pieces)
[0063] Inner Tablet Prescription:
[0064] Rifampicin 120g
[0065] Starch 10g
[0066] Hypromellose 8g
[0067] Cross-linked polyvinylpyrrolidone 4g
[0068] Povidone K 30 1.25g
[0070] Outer prescription:
[0071] Isoniazid 80g
[0072] Pyrazinamide 250g
[0073] Starch 20g
[0074] Cross-linked polyvinylpyrrolidone 3g
[0075] Povidone K 30 1.5g
[0076] Magnesium Stearate 2g
[0077] (3) Prescription of inner film film coating:
[0078] Hydroxypropyl methylcellulose 2910 1.5g
[0079] Polyethylene glycol 6000 1.5g
[0080] 95% ethanol 72ml
[0081] Distilled water 8ml
[0082] The preparation process is the same as in Example 1.
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