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Compound formula preparation eontaining glucocorticoid medicine

A production method and technology of compound preparations, applied in the field of compound preparations, can solve the problems of lack of glucocorticoids, etc., achieve the effect of convenient administration and elimination of iatrogenic adrenal hyperfunction

Active Publication Date: 2006-10-18
YOUCARE PHARMA GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] So far, there is no report on the production method of glucocorticoids combined with Zhimu to make compound preparations as a drug for glucocorticoid indications

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Prednisone (prednisone) + Zhimu extract is prepared into a compound preparation.

[0021] The extraction method of Anemarrhena is to use ethanol-water mixture (volume percentage of ethanol 60-80%), and soak the mixture for 3 times. Recover the ethanol under reduced pressure until it becomes a thick paste, combine the thick paste three times, add water to stir to dissolve, refrigerate, and discard the precipitate; the supernatant is concentrated to dryness under reduced pressure, let cool, and then add a small amount of methanol or ethanol to dissolve , add acetone to precipitate a white precipitate, wash the precipitate with acetone, and dry under reduced pressure to obtain the mother extract. That is to say, the Anemarrhena extract is a substance dissolved in ethanol and water mixed with an extraction solvent and precipitated in acetone, and this type of substance is mainly composed of anemarrhena total saponins. The extraction rate is about 2-3%.

[0022] Take by we...

Embodiment 2

[0024] Prednisone (prednisone) + Anemarrhena extract is made into compound granules.

[0025] The extraction method of Anemarrhena extract is the same as in Example 1, and the volume-to-powder ratio of ethanol-water mixture ethanol should be 40-50%.

[0026] Weigh 200 grams of the above Anemarrhena extract, and another 10 grams of prednisone, add excipients, such as dextrin, starch, powdered sugar in an appropriate amount, mix well, add 80% ethanol to wet soft material, and pass through a 20-mesh sieve Granulate, dry at 70°C to a moisture content of 4%±, pack into 2000 bags, and make granules.

Embodiment 3

[0028] Prednisone (prednisone) + Anemarrhena extract is made into oral solution.

[0029] The extraction method of Anemarrhena extract is the same as that in Example 1, except that the volume-to-powder ratio of ethanol-water mixture ethanol is changed to 30-40%.

[0030] Weigh 100 grams of the above Anemarrhena extract, and weigh 1000 grams of prednisone, add a small amount of sucrose to taste, and add water to 200,000 ml, pack into 100 ml or 10 ml each, fill and seal, and prepare oral liquid.

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Abstract

A production method of a compound preparation containing glucocorticoid medicine, comprising the following steps: the raw materials are prednisone and Anemarrhena anemarrhena, the extraction of Anemarrhena anemarrhena uses ethanol-water mixture for extraction, recovers under reduced pressure to a thick paste, dissolves in water, Refrigerate, discard the precipitate, concentrate the supernatant to dryness under reduced pressure, let it cool, add a small amount of methanol or ethanol to dissolve, add acetone to precipitate a white precipitate, wash the precipitate with acetone, and dry under reduced pressure; wherein the volume percentage of ethanol in the ethanol-water mixture is 30~80%; the weight ratio of prednisone and Anemarrhena anemarrhena extract is 10: 1~200; Get two medicines and mix, further make oral preparation; Compound preparation of the present invention can treat its indication without affecting glucocorticoid On the basis of the curative effect, reduce or even eliminate the adverse reaction of long-term application of glucocorticoids, meanwhile, the compound preparation of the present invention is convenient to use, and the compound preparation of the present invention has stable quality through stability investigation.

Description

【Technical field】 [0001] The invention relates to a production method of a compound preparation containing glucocorticoid medicine. 【Background technique】 [0002] Glucocorticoids (Glucocorticoids) mainly have anti-inflammatory and immune-suppressing effects, and are widely used clinically, such as in the treatment of nephrotic syndrome. However, long-term use of glucocorticoids in large quantities can cause many adverse reactions, such as iatrogenic adrenal hyperfunction, manifested as muscle weakness, full moon face, buffalo back, elevated blood sugar and blood lipids, etc., because glucocorticoids can reduce The defense ability of the body, and has no antibacterial effect, so it can induce infection or spread potential lesions in the body, such as viruses, molds, Mycobacterium tuberculosis, etc. At the same time, long-term use of glucocorticoids can also lead to accelerated protein decomposition in the body, negative nitrogen balance, and bone formation. Production decre...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8964A61K31/573A61P29/00A61P37/06A61P13/12
Inventor 于圣臣韩丽萍李俭洪
Owner YOUCARE PHARMA GROUP
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