Method for preparing microcapsule by high-voltage electric field encystation and low-temperature extraction and solidification

Abstract

The invention discloses a method for preparing microcapsules by low-temperature extraction and solidification in a high-voltage electric field. Under the action of the propeller, by adjusting the electric field voltage and liquid level, liquid balls of different particle sizes are made; the liquid balls are dropped into the liquid nitrogen container to freeze and solidify the liquid balls into balls; the container is placed at -60°C to -90°C In a low-temperature environment, the solid spheres dissolve slowly; then the acetone is taken away by the extractant, the polymer is deposited, and the microcapsules are solidified; they are washed with deionized water, centrifuged, and freeze-dried for storage. The actual effect of this method is: this method can prepare microcapsules with regular shape, good dispersion, and high drug loading capacity in encapsulation efficiency, which overcomes the low encapsulation efficiency, poor dispersion, and easy Reunion flaws.

Description

technical field [0001] The invention relates to a new process for preparing biodegradable sustained-release microcapsules, in particular to a method for preparing microcapsules by high-voltage electric field encapsulation, low-temperature extraction and solidification. Background technique [0002] Microencapsulation technology has been developed for decades. It has been found that microspheres made of drugs coated with wall materials through microencapsulation technology have the advantages of improving drug stability, achieving sustained or controlled release of drugs, and improving biocompatibility. However, most of the natural polymer wall materials discovered earlier cannot be degraded in the body and easily cause accumulation in the body. They are not suitable for intravenous injection and subcutaneous implantation, which limits the application of microcapsule products in the human body. In recent years, people have developed artificially synthesized biodegradable pol...

AI Technical Summary

Problems solved by technology

The double-emulsion method has gone one step further on the basis of the single-emulsion method, but it also has shortcomings: ①The sudden release of microcapsules is serious; ②The shape of the microcapsules is irregular, easy to aggregate, and the dispersion is not good; ③Add emulsification Agents and surfactants, protein drugs are easy to denature; ④The loss of drugs in the water phase still exists, and the encapsulation efficiency is general, etc.

The microcapsule particles prepared by the phase separation (coagulation) method are easy to agglomerate, which is difficult for practical production and application; and although the PLA and PLGA microcapsules can be successfully prepared by the spray drying method, the microcapsules will adhere to the spray-drying process during the preparation process. The inner wall of the container, which causes a large loss of product during the spray-drying process and agglomerates the product

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