Chuanxiongzine modified anticoagulant fimbrin material and its preparing method
A technology of silk fibroin and ligustrazine, applied in the field of biomedical materials
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preparation example 1
[0012] (1) Preparation of side chain functionalized ligustrazine
[0013] Prepare 2-formic acid-3,5,6-trimethylpyridine according to the literature (see "Synthesis of Metabolites of Ligustrazine in vivo [J]" Journal of Shandong Medical University, 1997, 1, 65; Author: Liu Xinyong et al. [1]) 6.3 grams of potassium permanganate were dissolved in 100 milliliters of water, and 2.7 grams of tetramethylpyrazine were dissolved in 20 milliliters of water. The two aqueous solutions were mixed and reacted at 70° C. for 2 hours. Filter and adjust the filtrate to acidic with hydrochloric acid. After standing still, crystals were precipitated. The measured melting point is 116-120°C. FTIR (KBr): 1720cm -1 (C=O, carbonyl in formic acid), 1436cm -1 (-N=C-, pyrazine ring).
[0014] (2) Preparation of silk fibroin film
[0015] Silk in 1% NaHCO 3 Boil in the solution to remove gum, dissolve in CaCl at 80°C 2 : C2H5OH: H2O=1: 2: 8 (molar ratio) solution and then dialyzed for three day...
preparation example 2
[0024] (1) The preparation method of side chain functionalized ligustrazine is the same as that of Preparation Example 1.
[0025] (2) Preparation of silk fibroin / Ligustrazine blend film
[0026] The preparation method of silk fibroin solution is the same as Preparation Example 1. Mix 20 milliliters of silk fibroin solution with 1 milliliter of 4% (w / v) ligustrazine aqueous solution, stir, pour into a petri dish, and form a film overnight in a constant temperature drying oven at 50°C.
[0027] (3) Surface chemical modification of silk fibroin / ligustrazine blend film
[0028] 1 g of 2-formic acid-3,5,6-trimethylpyrazine and 5 g of DCCI were dissolved in 100 ml of DMF, and an appropriate amount of silk fibroin / ligustrazine blend film was added, and electromagnetically stirred. After reacting at room temperature for 4 days, the silk fibroin film was taken out and washed with water several times, and dried at room temperature. ATR-FTIR: 1720cm -1 ~1750cm -1 (C=O) (ester bond)...
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