Peptide composition as immunogen for treatment of allergy

Abstract

The invention provides peptides comprising a sequence homologous to a portion of the third constant domain of the epsilon heavy chain of IgE, covalently linked to either (1) a carrier protein, or (2) a helper T cell epitope, and optionally to other immunostimulatory sequences as well. The invention provides for the use of such peptides as immunogens to elicit the production in mammals of high titer polyclonal antibodies, which are specific to a target effector site on the epsilon heavy chain of IgE. The peptides are expected to be useful in pharmaceutical compositions, to provide an immunotherapy for IgE-mediated allergic diseases.

Description

Invention field

[0001] The present invention relates to the application of a peptide binding composition as an immunogen. Each peptide conjugate contained therein includes a third constant region located in the heavy chain of IgEε (CH 3 ), the target antigen site is covalently connected (1) a carrier protein by chemical coupling, or (2) a helper T cell epitope by chemical coupling or by direct synthesis and Other immunostimulatory sequences are used to treat allergies.

[0002] More specifically, the present invention relates to the application of the peptide binding composition as an immunogen to induce the production of high-titer polyclonal antibodies specific to the target effector on the heavy chain domain of IgEε in mammals including humans, and also relates to the composition As a drug application, it provides immunotherapy for IgE-mediated allergies. Background of the invention

[0003] In the immune system of humans and other mammals, IgE mediates type I hypersensitivity...