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Permeable medical polyurethane film and its prepn and application

A technology of polyurethane and gas-permeable membranes, applied in medical science, prostheses, dilators, etc., can solve problems such as long-term curative effect and tissue necrosis, and achieve the effect of avoiding normal tissue necrosis

Inactive Publication Date: 2007-05-16
SHANGHAI INST OF APPLIED PHYSICS - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the currently used covering film is a dense material, which covers the surface of normal tissues for a long time, easily causing normal tissue necrosis, and the long-term efficacy is not optimistic

Method used

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  • Permeable medical polyurethane film and its prepn and application
  • Permeable medical polyurethane film and its prepn and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Dissolve Jm80 medical polyurethane in tetrahydrofuran to prepare a 20% (mass percentage) slurry, and let it stand for about 24 hours to ensure full dissolution and defoaming, and the obtained saturated medical polyurethane solution is ready for use.

[0028] Take a piece of flat glass and go through surface cleaning treatments such as acetone cleaning-blowing-drying-water cleaning-blowing-drying successively. Brush a layer of polyurethane slurry on the glass surface with a thickness of about 50 microns. Pre-drying in air at 25°C and 60% relative humidity for 5 minutes until the membrane is semi-dry, and the semi-dry membrane together with the glass plate is immersed in water to fully solidify the membrane gel. Take out the glass plate and carefully peel off to obtain the medical polyurethane breathable membrane of the present invention.

[0029] The appearance of the polyurethane film is pale white and almost transparent. The two surfaces of the film have different microsco...

Embodiment 2

[0031] Dissolve Jm80 medical polyurethane into N,N-dimethylformamide to prepare a slurry of 18% (mass percentage), and add 2% (volume percentage) of acetone to the slurry to ensure full dissolution and defoaming before use. Brush a layer of polyurethane slurry on the clean glass surface with a thickness of about 100 microns. Pre-drying in air at 15°C and 50% relative humidity for 10 minutes until the film is semi-dry, immerse the glass plate in a sodium chloride solution to fully gel and solidify. Take out the glass plate and carefully peel off to obtain the medical polyurethane breathable membrane of the present invention. Observing the surface morphology of the film under an electron microscope, 0.1 to 1 micron micropores are also formed in the film.

Embodiment 3

[0033] Dissolve Jm80 medical polyurethane into N,N-dimethylformamide to prepare a slurry of 18% (mass percentage), and add 5% (volume percentage) of methyl ethyl ketone to the slurry to ensure full dissolution and defoaming before use. Brush a layer of polyurethane slurry on the clean glass surface with a thickness of about 60 microns. Pre-drying in air at 30°C and 80% relative humidity for 2 minutes until the film is semi-dry, immersing the glass plate in an ethanol solution to fully gel and solidify. Take out the glass plate and carefully peel off to obtain the medical polyurethane breathable membrane of the present invention. Observing the surface morphology of the film under an electron microscope, 0.1 to 1 micron micropores are also formed in the film.

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Abstract

The present invention discloses one kind of medical permeable polyurethane film with pores of 0.1-1 diameter pores. The present invention also discloses the liquid phase transfer process for preparing the permeable polyurethane film. The medical permeable polyurethane film of the present invention is used as esophagus rack and rack for other human body channel, can prevent cell from growing into inside the rack to avoid re-stenosis, and has permeability to avoid the necrosis of health tissue outside the rack.

Description

Technical field [0001] The invention relates to the field of medical polyurethane membranes, in particular to a medical polyurethane breathable membrane and a preparation method and application thereof. Background technique [0002] Patients with narrow human lumens such as the respiratory tract, digestive tract, and urinary tract have poor quality of life. Take esophageal cancer as an example. Due to tumor proliferation, local inflammation, edema, etc., the esophagus is narrowed, making it difficult for patients to eat and drink, and affect systemic nutrition. Surgical resection is still the first choice for the treatment of esophageal cancer. However, for advanced esophageal cancer, 50% to 60% of patients are seriously ill due to the tumor invading the surrounding tissues or accompanied by distant metastasis, and can only be applied to palliative treatment. Early palliative treatment methods are usually diversion surgery and radiotherapy. These treatments have common shortcomin...

Claims

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Application Information

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IPC IPC(8): A61L27/16A61F2/04A61M29/00
Inventor 赵兴科卞晓锴李文新
Owner SHANGHAI INST OF APPLIED PHYSICS - CHINESE ACAD OF SCI
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