Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

High-strength high-modulus absorbable calcium polyphosphate fibre/polylactide composition as intrabony fixing material and its preparing process

A technology of calcium polyphosphate and polylactide, applied in medical science, prosthesis and other directions, can solve problems such as affecting bone shaping and bone structure reconstruction, insufficient mechanical strength and stiffness, foreign body reaction, etc., and achieves low cost, high strength and so on. and the effect of improved stiffness and simple preparation process

Inactive Publication Date: 2002-08-14
石宗利 +1
View PDF1 Cites 13 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the insufficient mechanical strength and rigidity of the current absorbable fracture internal fixation (lower than normal human cortical bone), it can only be used to treat cancellous bone fractures in non-gravity parts with a low incidence, such as ankles, elbows, and long bones of the limbs The internal fixation of bone ends and craniofacial fractures cannot be applied to the internal fixation of long bone shaft fractures in the weight-bearing parts of the limbs with a high incidence
In addition, because the polymer molecular weight of SR-PLLA is too high (100×10 4 Dolton), and has a crystalline structure, which leads to a long time for in vivo degradation and absorption (40 months); due to the amorphous structure of the polymer of SR-PLLA, the degradation rate is too fast in the late stage of implantation, resulting in local sterility Sexual effusion and sinus formation; because these polymer materials are implanted in the body, they will cause foreign body reaction, local acidification pH decrease, and no osteoconduction and bone integration biological activity, thus affecting bone shaping and bone structure reconstruction

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0073] Example 1: Preparation steps of high-strength, high-modulus bone plate:

[0074] ① Select calcium polyphosphate fiber (CPPf) with a diameter of about 10+1.5 μm and a daily degradation rate of 1.00%, and cut it into long fibers of 200 mm;

[0075] ② Weighing;

[0076] ③Weigh 50×10 4 D(MV) is 99.9% polylactide (PLLA) with a purity of 99.9%, which is dissolved in a container at 1:80 with an organic solvent;

[0077] ④ Purify and extract polylactide (PLLA) with absolute ethanol 1:160;

[0078] ⑤ Vacuum-dry the extracted polylactide (PLLA) particles in an oven for at least 24 hours (temperature 30-60°C);

[0079] ⑥Dissolve the polylactide (PLLA) particles with a 1:80 organic solvent;

[0080] 7. The calcium polyphosphate long fibers weighed through the step 2. are hand-laid, and the film is made of polylactide (PLLA) dissolved through the step 6.;

[0081] ⑧The organic solvent in the CPPf / PLLA film treated by step ⑦ is naturally volatilized for 24 hours, and then vacuum...

example 2

[0084] Example 2: Preparation steps of high-strength, high-modulus cancellous snails:

[0085] ① Get calcium polyphosphate fiber (CPPf), cut into short fibers of 12mm;

[0086] ② Weighing;

[0087] ③ Simultaneously take polylactide (PLLA) with a purity of 99.9%, and dissolve it in a container with 1:80 dichloroethane;

[0088] 4. step 2. the calcium polyphosphate staple fiber (CPPf) weighing is mixed with the polylactide (PLLA) solution after step 3. processing;

[0089] 5. Purify the mixture of extraction step 4. with 1: 150 absolute ethanol;

[0090] ⑥ Naturally volatilize the organic solvent in the CPPf / PLLA mixture obtained in ⑤ for at least 24 hours, and then vacuum-extract the organic solvent in an oven for at least 24 hours (temperature 30-60°C);

[0091] ⑦ Plate hot press vacuum mold hot pressing, temperature 120-200 ℃, pressure 20-80Mpa;

[0092] ⑧Demoulding, sample modification, packaging, and sterilization to obtain high-strength and high-modulus loose internal ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A high-strength high-modulus absorble material as intrabony fixing material is prepared from calcium polyphosphate fibres as reinforcing component and polylactide as substrate in wt ratio of (1-80):(20-99). Its advantages include high compatibility to bone tissue, no poison and untoward effect, bio-degradable, and low cost.

Description

technical field [0001] The invention relates to a high-strength and high-modulus resorbable bone internal fixation composite material used in medicine for bone internal fixation, and belongs to the technical field of artificial body implantation. technical background [0002] In the past 40 years, artificial implants have been widely used in clinical medicine. Medical clinical practice has proved that the vast majority of artificial internal implants are safe and effective for the human body. The application of these artificial internal implants has greatly improved human health and quality of life. Artificial internal implants usually include permanent implants (such as artificial hip joints, knee joints, and heart valves, etc.). The artificial internal implants for permanent use are required to be made of medical materials with good biological stability, while the artificial internal implants for temporary use are made of biodegradable and absorba...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L27/46C08L67/04
Inventor 石宗利戴刚
Owner 石宗利
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com