Unlock instant, AI-driven research and patent intelligence for your innovation.

Polyasparagine derivative containing high-activity hydroxy radical

A technology for polyasparagine and derivatives, applied in the field of polyasparagine derivatives, can solve the problems of unfavorable polar drug chemical bonding, unfavorable chemical bonding drugs, and small number of active hydroxyl groups, and achieves simple and easy preparation methods, Widely popularized and applied, the effect of large drug loading

Inactive Publication Date: 2002-09-18
SURFACE & INTERFACE CHEM ENG TECH RES CENT NANJING UNIV
View PDF1 Cites 8 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As the chain length of the non-polar substituent increases, the lipophilicity of these polyasparagine derivatives gradually increases, but their hydrophilicity decreases, which is not conducive to the chemical bonding of polar drugs.
[0005] To sum up, at present, various polyasparagine derivatives generally have the problem that the number of active hydroxyl groups on the side chain is relatively small, which is not conducive to chemically bonding drugs.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Polyasparagine derivative containing high-activity hydroxy radical
  • Polyasparagine derivative containing high-activity hydroxy radical

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0012] The present invention will be described in further detail below in conjunction with the accompanying drawings.

[0013] According to the present invention, a polyasparagine derivative rich in active hydroxyl groups is prepared. Its preparation method is as follows: firstly weigh 200 grams of aspartic acid, add 10 grams of catalyst concentrated phosphoric acid, and carry out polycondensation reaction at 180 ° C. React for 10 hours, gradually reduce the pressure to 1×10 4 Pa, can make polysuccinimide (code name: PSI), productive rate 95%; Then 50 grams of PSI are dissolved in 250ml N, in the N-dimethylformamide (code name: DMF), be cooled to 0 ℃, start to drop 120 milliliters of diethanolamine at this temperature, react at room temperature for 4 hours, add the mixture dropwise to 1500 milliliters of n-butanol and keep stirring, filter after standing for 1 hour, wash with acetone until the pH value of the filtrate is neutral properties, vacuum drying at room temperature f...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A polyasparagine derivative containing high-activity hydroxy radicals for medical purpose is disclosed, which features high power of carrying chemical medicine.

Description

1. Technical field: [0001] The invention relates to a medical polyamino acid polymer compound, in particular to a polyasparagine derivative rich in active hydroxyl groups. 2. Background technology: [0002] Polyamino acids and their derivatives are a new type of medical polymer compounds with excellent biocompatibility, can be completely degraded and absorbed when acting on organisms, and are non-toxic and have no side effects. [0003] At present, American Signam company has already listed poly(α,β-N-hydroxyethyl-DL-aspartamide) [Poly-(hydroxyethyl-DL-aspartamide, code name: PHEA), its main application is prodrug carrier and Plasma substitute, the structural formula is: Due to the structure of the side chain -NH-CH 2 -CH 2 OH is used as a carrier, so the number of hydroxyl groups is relatively small, which is not conducive to chemically bonding drugs, and the cost of preparation is high, and the sales price of finished products is expensive, above 100 US dollars per gra...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C08G69/08
Inventor 沈健陈强
Owner SURFACE & INTERFACE CHEM ENG TECH RES CENT NANJING UNIV