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Method of producing penetrating pump capsule as one new dosage form

A technology of osmotic pumps and new dosage forms, which is applied in the field of medicine and can solve the problems of high price of enteric-coated capsules

Inactive Publication Date: 2002-09-25
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Enteric-coated capsules are more expensive

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0007] Appropriate amount of medicine, NaCl 15%, cellulose acetate 25.5g, polyethylene glycol 4000 4.5g

[0008] Weigh an appropriate amount of medicine, add sodium chloride accounting for 15% of the weight of the medicine, mix evenly, and pack into a certain type of capsule according to the amount. Weigh 25.5g of cellulose acetate, dissolve it with 970ml of acetone, then add 30ml of water containing 4.5g of polyethylene glycol 4000, stir evenly, coat the above-mentioned capsules as a coating solution, and punch holes to obtain.

Embodiment 2

[0010] Appropriate amount of medicine, KCl 20%, ethyl cellulose 20.5g, polyethylene glycol 4000 4.5g

[0011] Take an appropriate amount of medicine, add potassium chloride accounting for 20% of the medicine weight, mix evenly, and pack into a certain type of capsule according to the amount. Weigh 20.5g of ethyl cellulose, dissolve it with 900ml of ethyl acetate, then add 40ml of water containing 5.0g of polyethylene glycol 4000, stir evenly, coat the above-mentioned capsules as a coating solution, and punch holes to obtain .

Embodiment 3

[0013] Appropriate amount of medicine, starch 5%, cellulose acetate phthalate 27.5g, polyvinylpyrrolidone 5.0g

[0014] Weigh an appropriate amount of the medicine, add starch accounting for 5% of the medicine weight, mix evenly, and load it into a certain type of capsule according to the amount. Weigh 27.5g of cellulose acetate phthalate, dissolve it with 980ml of chloroform, then add 20ml of methanol containing 5.0g of polyvinylpyrrolidone, stir evenly, and use it as a coating solution to coat the above-mentioned capsules, and punch holes to obtain.

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PUM

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Abstract

The present invention is method of producing penetrating pump capsule as one new dosage form from common capsule. This kind of new dosage has the features of both common gastric coated capsule and enteric coated capsule and its medicine is controlled to release safely and in long action and absorbed in both stomach and intestines in certain propertion. With material similar those in common capsule, the medicine and active penetrating supplementary material are filled into capsule, and the capsule coating is coated with coating liquid in certain thickness before one or several holes are drilled.

Description

Technical field: [0001] The invention relates to the technical field of medicine, in particular to a method for making a common capsule into a new dosage form of an osmotic pump capsule. Background technique: [0002] Capsules are a dosage form developed from improving the conditions for taking medicine. Its development conforms to the world trend and there are many varieties, such as immediate-release capsules (that is, the capsule body and capsule cap have 10 small holes each, and the medicine can be quickly dissolved when loaded). , double-chamber capsules (that is, capsules with a separation layer to release drugs or sub-package drugs with incompatibility), sustained-release capsules, effervescent capsules, implant capsules, colon-targeted drug delivery capsules, magnetic capsules, etc., become One of the most widely used oral dosage forms. By 1986, the production capacity of capsules in my country had reached 26.4 billion capsules, and the development speed was signifi...

Claims

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Application Information

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IPC IPC(8): A61K9/48
Inventor 潘卫三李孝栋
Owner SHENYANG PHARMA UNIVERSITY
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