Process for extracting general platycodoside and platycoligenin D from platycodon root, its medical application and its Chinese medicine

A technology of Platycodon grandiflorum saponins and total saponins, which are applied in the directions of medical preparations containing active ingredients, chemical instruments and methods, pharmaceutical formulas, etc.

Inactive Publication Date: 2003-02-19
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AI-Extracted Technical Summary

Problems solved by technology

Using traditional Chinese medicine bellflower as raw material, a large number of bellflower total saponins and monomeric saponin...
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A process for extracting common platycodoside and platycodin D from platycodon root includes extracting in alcohol or water, depositing in alcohol for purifying it, purifying by macroreticular resin adsorbent column, drying to obtain common platycodoside, separating by chromatography, discriminating by thin silica gel layer, collecting the fractions with same Rf value, and volatilizing solvent to obtain platycodin D. They can be used for preventing and treating hyperglycemia and the complications caused by diabetes.

Application Domain

Sugar derivativesMetabolism disorder +3

Technology Topic

SolventChemistry +13


  • Experimental program(6)

Example Embodiment

[0052] Example 1
[0053] Extraction of Platycodon grandiflora total saponins: Take 1kg of the traditional Chinese medicine Platycodon grandiflorum, cut into 2mm thick decoction pieces, extract three times with 5 times the amount of 85% ethanol, or extract with water to extract 95% ethanol precipitation, and use 2% medicinal Decolorize with active carbon, filter, reclaim ethanol, then dilute to 1500ml with deionized water, filter, purify through D101 macroporous adsorption resin column, first wash 3000ml with deionized water, then elute with 85% ethanol, collect ethanol liquid, reduce Concentrate under pressure to recover ethanol, and dry the concentrate to obtain the total saponins of Platycodon grandiflora.

Example Embodiment

[0054] Example 2
[0055] The preparation of monomer platycodon saponin D: the platycodon total saponin 10g that embodiment 1 obtains is dissolved with methanol, filters, adds 50g chromatographic silica gel G and mixes evenly, dry, separate on middle and low pressure column chromatography, use n-butanol: Acetic acid: water (4:1:5) upper layer was used as developing solvent for separation. Identified by silica gel thin layer, the fractions of spots with the same Rf value were combined (the largest spot was platycodin D), and the solvent was evaporated to obtain the monomer platycodin D (Platycodin D).

Example Embodiment

[0056] Example 3
[0057] Platycodon grandiflorum total saponins 1kg, medicinal starch 0.5kg, wet granulation with 80% ethanol, granulate, dry, pack 1# capsules, each 0.2. Other items should meet the requirements of capsules in the Pharmacopoeia of the People's Republic of China in 2000.


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