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Process for extracting general platycodoside and platycoligenin D from platycodon root, its medical application and its Chinese medicine

A technology of Platycodon grandiflorum saponins and total saponins, which are applied in the directions of medical preparations containing active ingredients, chemical instruments and methods, pharmaceutical formulas, etc.

Inactive Publication Date: 2003-02-19
JILIN TIANYAO SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Using traditional Chinese medicine bellflower as raw material, a large number of bellflower total saponins and monomeric saponin D are prepared and made into hypoglycemic drugs for the prevention and treatment of diabetes, which has not been reported so far

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Extraction of Platycodon grandiflora total saponins: Take 1kg of the traditional Chinese medicine Platycodon grandiflorum, cut into 2mm thick decoction pieces, extract three times with 5 times the amount of 85% ethanol, or extract with water to extract 95% ethanol precipitation, and use 2% medicinal Decolorize with active carbon, filter, reclaim ethanol, then dilute to 1500ml with deionized water, filter, purify through D101 macroporous adsorption resin column, first wash 3000ml with deionized water, then elute with 85% ethanol, collect ethanol liquid, reduce Concentrate under pressure to recover ethanol, and dry the concentrate to obtain the total saponins of Platycodon grandiflora.

Embodiment 2

[0055] The preparation of monomer platycodon saponin D: the platycodon total saponin 10g that embodiment 1 obtains is dissolved with methanol, filters, adds 50g chromatographic silica gel G and mixes evenly, dry, separate on middle and low pressure column chromatography, use n-butanol: Acetic acid: water (4:1:5) upper layer was used as developing solvent for separation. Identified by silica gel thin layer, the fractions of spots with the same Rf value were combined (the largest spot was platycodin D), and the solvent was evaporated to obtain the monomer platycodin D (Platycodin D).

Embodiment 3

[0057] Platycodon grandiflorum total saponins 1kg, medicinal starch 0.5kg, wet granulation with 80% ethanol, granulate, dry, pack 1# capsules, each 0.2. Other items should meet the requirements of capsules in the Pharmacopoeia of the People's Republic of China in 2000.

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Abstract

A process for extracting common platycodoside and platycodin D from platycodon root includes extracting in alcohol or water, depositing in alcohol for purifying it, purifying by macroreticular resin adsorbent column, drying to obtain common platycodoside, separating by chromatography, discriminating by thin silica gel layer, collecting the fractions with same Rf value, and volatilizing solvent to obtain platycodin D. They can be used for preventing and treating hyperglycemia and the complications caused by diabetes.

Description

Technical field: [0001] The invention discloses a method for extracting total saponins and monomer platycodon saponin D from platycodon grandiflorum. At the same time, the new medical application of the total platycodon saponins and monomer platycodon saponin D and its traditional Chinese medicine preparation are disclosed, belonging to the technical field of extracting and preparing active ingredients of Chinese medicine and its new medical application. Background technique: [0002] Campanulaceae [Platycodon grandflorum (Jacq.) A.DC.] is one of the most commonly used traditional Chinese medicines. Traditional Chinese medicine is often used to treat various diseases such as cough with excessive phlegm, chest tightness, and cold and sore throat. Modern pharmacological studies have shown that Platycodon grandiflorum also has obvious anti-inflammatory, inhibitory gastric acid secretion and anti-ulcer effects, and also has the effect of lowering cholesterol in rats. It has not...

Claims

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Application Information

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IPC IPC(8): A61K31/70A61P3/10C07H1/08
Inventor 赵全成杨明
Owner JILIN TIANYAO SCI & TECH
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