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Chinese medicine preparation containing ophiopogon root total saponin and preparation method

A technology of traditional Chinese medicine preparation and total saponins, which is applied in the field of preparation and preparation of traditional Chinese medicine preparations containing total saponins of Ophiopogon japonicus, can solve problems such as not seen, and achieve the effect of improving the purity

Inactive Publication Date: 2003-04-30
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there is no research data on the comprehensive investigation of the anti-myocardial ischemia effective parts of Radix Ophiopogon japonicus with a large class of components as the research object, and there is no Chinese medicine preparation with high content of total saponins of Radix Ophiopogon japonicus as the active ingredient for clinical use.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] The specific embodiment embodiment 1 the preparation of Ophiopogon japonicus total saponins extract:

[0050] Take Ophiopogon japonicus medicinal material (10 meshes), reflux three times with 10 times the amount of 80% ethanol, recover the ethanol from the ethanol extract to 1:1, add 95% ethanol to the solution until the alcohol content is 75%, and let it stand overnight. Filter, reclaim ethanol to 1: 1, macroporous resin (D-101 type) on the solution, sample amount is macroporous resin (dry weight): crude drug=1: 10, wash with water until Mollish reaction is negative, wash with 80% ethanol Remove until the Liberman reaction is negative, the eluate is decompressed and the solvent is recovered to obtain the total saponins of Ophiopogon japonicus, and the content is 62%. Example 2 Tablet preparation:

Embodiment 2

[0051] Auxiliary materials such as micropowder silica gel, microcrystalline cellulose are pulverized respectively through 100 mesh sieves, 150g of Ophiopogon japonicus total saponins extract containing 62% of Ophiopogon japonicus total saponins prepared by the method of embodiment 1, mix homogeneously with 100g sodium carboxymethyl starch, mix with 25g The starch slurry is made into a soft material, passed through a 20-mesh sieve, dried, granulated through a 20-mesh sieve, added with 150g of micropowder silica gel, 500g of microcrystalline cellulose, and magnesium stearate, mixed in an appropriate amount, and then pressed into tablets to obtain 1,000 tablets. The weight of the alcohol-adjusted tablet is 1.0 g. Example 3 Preparation of granules:

Embodiment 3

[0052] Auxiliary materials such as micropowder silica gel and microcrystalline cellulose are pulverized respectively through a 100-mesh sieve, and 170g of Ophiopogon japonicus total saponins extract prepared by the method in Example 1 and 100g of sodium carboxymethyl starch are mixed uniformly, and 25g of starch slurry is used to make a soft material. Pass through a 20-mesh sieve and dry at 60°C.

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PUM

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Abstract

An oral-applied solid Chinese medicine containing ophiopogonin for treating myocardial ischemia contains the ophiopogonin extract (5-40 wt%) and medical additive (60-95 wt.%). Its advantages are high quality stability and easy control to dosage.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation and a preparation method, in particular to a traditional Chinese medicine preparation containing total saponins of Ophiopogon japonicus and a preparation method. Background technique [0002] Ophiopogon japonicus (L.f.) ker-Gawl is the dry root tuber of Liliaceae Ophiopogon japonicus (L.f.) ker-Gawl. It is a commonly used traditional Chinese medicine for nourishing yin. It has the functions of nourishing yin and promoting body fluid, moistening the lungs and clearing the heart, and can be used for diseases such as febrile disease, body fluid injury, upset and thirst. The research found that Ophiopogon japonicus contains steroidal saponins, high isoflavones, polysaccharides, amino acids and other ingredients. Yang Zhi et al reported in "West China Pharmaceutical Journal" 1987; 2 (3), isolated four kinds of saponins from Ophiopogon japonicus, as ophiopognin D ', ophiopognin D etc.; In ...

Claims

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Application Information

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IPC IPC(8): A61K31/70A61P9/10
Inventor 徐德生周跃华冯怡刘力吴笑如
Owner SHANGHAI UNIV OF T C M
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