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Medicine for treating cholecithes and its preparation method

A technology for biliary tract stones and production methods, which is applied in the direction of pharmaceutical formulas, medical preparations containing active ingredients, drug combinations, etc., can solve problems such as toxic reactions, poor curative effect, strong mucosal irritation, etc., and achieve no toxic side effects, application Convenience and simple effects

Inactive Publication Date: 2003-07-16
NO 261 HOSPITAL PLA
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

Nine kinds of drugs were used, including dimethyl tert-butyl ether, ethyl tert-butyl ether, monocaprylic glyceride, etc., but the toxicology was unqualified, the curative effect was not good, and it was not popularized.
[0004] Taking dimethyl tert-butyl ether as an example, the problems in toxicology are: 1. Strong irritation to the mucous membrane; 2. The contact between the drug and the adjacent organs of the gallbladder will cause damage to the adjacent organs; 3. After the drug is decomposed and absorbed, the whole body has toxic effects. toxic reaction
The problems in curative effect are: 1. It is only effective for cholesterol stones; 2. There are residual stones after treatment.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Select 950 milliliters of refined soybean oil, use 50 grams of phosphatidylcholine prepared from soybean for intravenous injection, mix in a container, and stir until the solution of phosphatidylcholine particles is not seen in the soybean oil; autoclave after sealing ; Filtration, sub-installation ampoules are sealed.

Embodiment 2

[0028] Select 870 milliliters of refined soybean oil, use 130 grams of phosphatidylcholine for intravenous injection prepared from soybean, mix in a container, and stir until the solution of phosphatidylcholine particles is not seen in the soybean oil; autoclave after sealing ; Filtration, sub-installation ampoules are sealed.

Embodiment 3

[0030] Select 920 milliliters of refined soybean oil, use 80 grams of phosphatidylcholine for intravenous injection prepared from soybean, mix in a container, and stir until the solution of phosphatidylcholine particles is not seen in the soybean oil; autoclave after sealing ; Filtration, sub-installation ampoules are sealed.

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Abstract

A medicine for treating cholelithiasis uses refined soybean oil 950-870 ml and phosphatidylcholine prepared from soybean for injection 50-130 g by preparing through mixing, stirring, sealing, then high-pressure sterilizing filtering, and then split looding in ampulse and sealing. Its advnatages are high curative effect and no toxic by-effect.

Description

Technical field: [0001] The invention relates to a medicine for treating bile duct stones and a preparation method thereof. Background technique: [0002] At present, there are four methods for the treatment of biliary stones: surgery, drug expulsion, lithotripsy, and drug "dissolving stones". Each has indications and effects. [0003] Oral bile salt-dissolving medicine originated in 1937, and its efficacy is not clear. In the 1980s, some people at home and abroad successively studied the application of stone-dissolving drugs directly injected into the biliary system for the treatment of gallstones, which is to solve the treatment of some patients with cholelithiasis in the stationary phase or without surgery. The applied drugs include dimethyl tertiary butyl ether, ethyl tertiary butyl ether, monocaprylic acid glyceride, etc., but the toxicology is not satisfactory, the curative effect is not good, and it has not been popularized. [0004] Taking dimethyl tertiary butyl ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P1/16
Inventor 陈省山康金芳陈昌松鱼爱和范武峰
Owner NO 261 HOSPITAL PLA
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