Calixarene bonded silica gel immobile phase preparing process

Abstract

A process for preparing the chromatographic bonded immobile phase includes preparing gamma-epoxypropoxypropyl silica gel as precursor, reaction of sodium hydride calixarene in anhyrous toluene at 70-80 deg.C to obtain calixarene phenol sodium salt, carrying it on said precursor under the action of quaternary ammonium salt, and reaction in nitrogen or argon gas at 110-120 deg.c. Its advantages aresimple process, low cost and high acid stability.

Description

technical field [0001] The invention relates to a preparation method of a calixarene bonded silica gel stationary phase. Background technique [0002] Chromatography is the fastest growing and most widely used separation and analysis technology in modern analytical chemistry, and is developing into an efficient and energy-saving separation engineering technology, which is playing an increasingly important role in many fields such as chemistry, biology and biotechnology, medicine, and life sciences. more important role. The basic requirement of chromatographic analysis is to achieve the separation of the components of the mixture, and the essence of the separation is based on the difference in the interaction between the analyzed solute and the mobile phase and stationary phase. Among them, the development of highly selective stationary phase is the core field of chromatography system. Among the many chromatographic stationary phases, silica gel and modified silica gel were...

AI Technical Summary

Problems solved by technology

Since then, although there have been related reports, there are very few types of calixarene bonded phases, and the reported bonding reactions are narrowly applicable and the preparation process is complicated.