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Bioabsorbable fracture internal-fixing material and preparing method thereof

A fixation material and biological technology, applied in the field of biological material and its preparation, chitin fiber reinforced polycaprolactone bioabsorbable fracture internal fixation material and its preparation field, can solve the problem that degradation products are easy to cause complications, the degradation rate is fast, High price and other problems, to achieve the effect of convenient source of raw materials, slow degradation rate, and improved compatibility

Inactive Publication Date: 2004-04-14
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The experimental results reported in the literature show that for the most studied PGA and PLA orthopedic implants, the degradation rate is fast; the degradation products are easy to cause complications; the melting point is high and the processing is difficult; the source is less and the price is relatively expensive; Becoming a limiting factor for the use of polylactic acid as a fracture internal fixation material

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Stir 150g of chitin fiber, 50g of butyrylated chitin, and 800g of PCL in a high-speed mixer for 15 minutes to make them evenly mixed, and then knead, crush and mold them in an internal mixer at a high temperature of 140°C. The molded composite plate was irradiated with an electron beam in an electron beam accelerator, and the irradiation dose was 200kGy.

Embodiment 2

[0013] Stir 340g of chitin fiber, 60g of butyrylated chitin, and 600g of PCL in a high-speed mixer for 10 minutes to make them evenly mixed, and then knead, crush and mold them in an internal mixer at a high temperature of 150°C. The molded composite plate was irradiated with an electron beam in an electron beam accelerator, and the irradiation dose was 200kGy.

Embodiment 3

[0015] Stir 450g of chitin fiber, 50g of butylated chitin, and 500g of PCL in a high-speed mixer for 20 minutes to make them evenly mixed, and then knead, crush, and mold them in an internal mixer at a high temperature of 160°C. The molded composite plate was irradiated with an electron beam in an electron beam accelerator, and the irradiation dose was 200kGy.

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PUM

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Abstract

The invention is a bio-absorbable internal-fracture-fixation material and preparing method. Its components (wt%): polycaprolactone 30-80%, 15-65%, and denatured chitin fiber 0-10%. It weighs the components proportionally, blends for 10-20 min until even, then at 130-160íµ mix-refines, crushes / squeezes, and shapes. It has good biocompatibility.

Description

technical field [0001] The invention relates to a biological material and a preparation method thereof, in particular to a chitin fiber reinforced polycaprolactone bioabsorbable fracture internal fixation material and a preparation method thereof, belonging to the field of composite materials. Background technique [0002] At present, fracture internal fixation materials mainly include metal internal fixation materials, shape memory alloy materials, and bioself-absorbing composite materials. At present, the internal fixation devices for fractures in clinical use are mainly metal materials such as stainless steel, titanium and their alloys. Although these materials are relatively perfect in terms of stiffness, strength and biocompatibility, they have stress shielding effects, metal erosion and often require Issues such as reoperation and removal have not yet been resolved. Bioabsorbable materials are mainly composed of biodegradable polymer materials. After implanted in the ...

Claims

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Application Information

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IPC IPC(8): A61L31/12A61L31/14
Inventor 孙康吴人洁陈长春杨安乐乔秀颖
Owner SHANGHAI JIAO TONG UNIV