Fiter for processing blood and producing method for same

A technology of filters and preparations, applied in blood circulation treatment, chemical instruments and methods, separation methods, etc., can solve problems without any research

Inactive Publication Date: 2004-04-14
ASAHI KASEI MEDICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the invention of this application, there is no research on the simultaneous removal of leukocytes and platelets from whole blood or red blood cell preparations

Method used

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  • Fiter for processing blood and producing method for same
  • Fiter for processing blood and producing method for same
  • Fiter for processing blood and producing method for same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-1

[0139] (Preparation of Polymer Coating Solution)

[0140] In a copolymer formed by 97 mol% of 2-hydroxyethyl (meth)acrylate and 3 mol% dimethylaminoethyl (meth)acrylate (weight average molecular weight 570,000, content of basic nitrogen atom 0.32% by weight , non-ionic hydrophilic group 97 mol%, the amount of basic nitrogen atoms 3 mol%, peak molecular weight 3.75×10 5 , content of low molecular weight components 26.0%) to form a polymer solution (copolymer concentration 39% by weight, ethanol solution) was added 4 times the volume of ethanol and uniformly dissolved at 40 ° C. After the liquid-liquid phase separation was performed by the thermally induced phase separation method by leaving this solution at room temperature of 25° C. for 12 hours, only the polymer-rich layer solution (copolymer concentration: 31% by weight) was recovered respectively.

[0141] It was confirmed that in the obtained polymer-rich layer solution, the content of dissolved basic nitrogen atoms was 0...

Embodiment 1-2

[0170] The same procedure as in Example 1-1 was carried out except that ethanol was added to the polymer-rich layer solution used in Example 1-1, and a polymer solution having a copolymer concentration of 1.25% by weight was used. Polymer coating in the filter is 9.55 mg / m 2 , the coverage rate is 50%.

[0171] The blood evaluation results at this time are shown in Table 1. A high leukocyte removal efficiency is obtained. In addition, a high removal efficiency of 95% or more was obtained in the platelet removal rate.

Embodiment 1-3

[0173] Instead of the nonwoven fabric used in Example 1-1, a nonwoven fabric (40 g / m2) formed of poly(trimethylene terephthalate) fibers with an average fiber diameter of 1.2 μm was used. 2 Eye pay, porosity 75%, thickness 0.23mm, density 0.17g / cm 3 , width 300mm, specific surface area 1.98m 2 / g), the same operation as in Example 1-1 was carried out. Polymer coating in the filter is 0.54mg / m 2 , The coverage rate is 20%.

[0174] Table 1 shows the evaluation results of the blood at this time. A high leukocyte removal efficiency is obtained. In addition, high platelet removal performance of 95% or more was obtained in the platelet removal rate.

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Abstract

A filter for reducing leukocytes and platelets from an erythrocyte preparation or a whole blood preparation which is characterized by having a filter base coated with a polymer, the content of the polymer being from 0.5 to 10 mg / m2 per unit area of the total surface of the filter base, and the polymer containing 20% or less of low-molecular weight components having a molecular weight not more than 1 / 4 of the peak top molecular weight in the gel permeation chromatogram. In addition, the invention also relates to a process for producing the filter.

Description

【Technical field】 [0001] The present invention relates to a filter for blood treatment. More specifically, the present invention relates to a filter for simultaneously removing white blood cells and platelets from a red blood cell preparation or a whole blood preparation, and a method for producing the same. 【Background technique】 [0002] In the field of blood transfusion, in addition to the so-called whole blood transfusion in which an anticoagulant is added to the blood collected from the donor, blood components necessary for the donor are separated from the whole blood and then transfused. The injection is the so-called component transfusion. Component blood transfusions include red blood cell transfusion, platelet transfusion, plasma transfusion, etc. depending on the blood components required by the donor, and the blood component preparations used include red blood cell preparations, platelet preparations, and plasma preparations. [0003] In addition, in these whole...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M1/36B01D39/16B01D39/20B01J20/26
CPCB01J20/26A61M2202/0439B01D2239/0471B01J2220/66B01D39/1623A61M1/3633B01D39/16
Inventor 大石辉彦三浦司和
Owner ASAHI KASEI MEDICAL CO LTD
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