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Nanometertechnology preparation method of fat emulsion injection liquid

A nanotechnology, fat emulsion technology, applied in the field of nanotechnology preparation of fat emulsion injection, can solve the problems of difficult drugs, poor absorption, large particles, etc.

Inactive Publication Date: 2004-06-16
苟仕金
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But at present, the particles are larger, insoluble in some drugs, and poorly absorbed

Method used

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  • Nanometertechnology preparation method of fat emulsion injection liquid
  • Nanometertechnology preparation method of fat emulsion injection liquid
  • Nanometertechnology preparation method of fat emulsion injection liquid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0088] Embodiment 1: fat emulsion for intravenous injection

[0089] [Materials and dosage] Soybean oil (refined) 150g soybean lecithin (refined) 12g glycerin (for injection) 25g water for injection add to 1,000ml.

[0090] [Preparation method] Take refined soybean lecithin, put it in a high-speed tissue masher, add glycerin and water for injection and stir it until uniform under nitrogen flow, then pour it into a nano collider, adjust the oil to control 50-60nm cracking and dispersing, and place In the liquid storage tank, pass nitrogen gas, filter, sterilize, and pack.

[0091] [Quality inspection] includes oil dispersion, fat and glycerin content, free fatty acid content, pH value, peroxide value, fat diameter, pyrogen, sterilization, allergen, abnormal toxicity, stability, etc.

[0092] [Use] Intravenous injection of fat emulsion is used for peripheral intravenous nutrition to supply essential fatty acids. It is suitable for those who have difficulty or cannot eat before...

Embodiment 2

[0093] Example 2: Injectable Fat Emulsion Influenza Vaccine

[0094] [Materials and dosage] 250g of refined soybean oil, 20g of refined soybean lecithin, 150g of Tween, 45000 micrograms of purified influenza vaccine (whole virus, cracked and subunit), 30 grams of glycerin, and water for injection to 1000ml.

[0095][Preparation method] Take refined soybean oil, phospholipids, Tween 80 plus glycerin, influenza vaccine antigen and water for injection, put them in a high-speed tissue masher and mix them thoroughly, then pour them into a nano collider, adjust 20-30nm and store in In the liquid storage tank, filter and pack. Each tube is 1 ml, and each tube contains 115 units of influenza antigen A. A 315 units, B type 15 units, 45 units each. Store at 2-8°C, pay attention to operate under low-temperature sterile conditions.

[0096] [Quality Inspection] According to the fat emulsion injection project and influenza vaccine project

[0097] [Usage] For the prevention of influenz...

Embodiment 3

[0099] Embodiment 3: Inhalation medicinal freeze-dried fat nanoparticle powder

[0100] Take 2g of Amphotericus B (antifungal drug), add 100g of refined soybean lecithin and 150g of refined soybean oil, and the fat emulsion made by nanotechnology treatment is yellow and transparent. The reinjected emulsion was sterilized by filtration through a 0.22m filter membrane. Fill into injection ampoules, each 2.0ml, freeze-dried, capped and sealed. That is, inhalation freeze-dried fat nanoparticle powder.

[0101] The lyophilized powder for inhalation can also be made into a particle diameter of 0.5-4. n, filled in a hard capsule shell, 0.25g per capsule. This step yields 1.25 mg amphotericin B per micelle. The capsules can be pierced with a nebuliser-powder inhaler and the contents are directly inhaled.

[0102]

[0103] model

NT1500 / 5

Maximum throughput

5L / hr

power consumption

1.5KW

Minimum throughput

30ml

weight

11+36...

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Abstract

A process for preparing fat milk injection by nano technique comprising, mixing refined soyabean oil, refined lecithin , glycerin and water for injection, high speed stirring, nanometer decomposition, filtration and loading. The safety of soybean as oil phase and lecithin as emulsifying agent in human body is already confirmed. The particle diameter in the range of 1-100nm can be regulated freely, the particle surface electrical property can also be controlled, the water indissolvable medicine can be dissolved in oily phase, thus increasing the preparation stability and controlling diffusion, resulting a slow release.

Description

[0001] Field [0002] The invention relates to a method for preparing fat emulsion injection, in particular to a method for preparing fat emulsion injection by nanotechnology. Background technique [0003] Fat emulsion is a concentrated nutritional solution for parenteral high-calorie supplementation. A small amount of infusion can meet most of the calories needed by the human body, so that patients who cannot eat, lack nutrition, and are physically weak can obtain nutritional supplements, which is beneficial to save the consumption of the human body and support the treatment of various serious diseases. But at present, the particles are relatively large, insoluble in some drugs, and poorly absorbed. Contents of the invention [0004] The purpose of the present invention is to provide a kind of method utilizing nanotechnology to prepare fat emulsion injection. [0005] As an energy substance for nutritional support, fat emulsion is one of the major advances in the history ...

Claims

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Application Information

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IPC IPC(8): A61K9/107
Inventor 苟仕金苟鸿鹰
Owner 苟仕金