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External use composition containing oil-soluble licorice extract and its stabilization method

A licorice extract, oil-soluble technology, applied in the directions of medical preparations, drug combinations, organic active ingredients, etc. containing active ingredients, can solve the problems of odor, damage to emulsification, mixing, etc., and achieve the effect of improving stability

Inactive Publication Date: 2004-08-18
MARUZEN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is a problem that the above-mentioned oil-soluble licorice extract is easy to solidify as it is, and even if it is made into a preparation, it will be colored and smelly when stored for a long time
According to this proposal, although glycyrrhizic acid glabra, one of the active ingredients of the oil-soluble licorice extract, can be stabilized, the oil-soluble licorice extract mixed with many components still cannot suppress the change of color and odor over time.
And there are the following disadvantages, or the decomposition of pyrosulfite and / or sulfite produces gas, or the stability of the preparation is affected by the amount of pyrosulfite and / or sulfite, which damages the emulsification and produces precipitation

Method used

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  • External use composition containing oil-soluble licorice extract and its stabilization method
  • External use composition containing oil-soluble licorice extract and its stabilization method
  • External use composition containing oil-soluble licorice extract and its stabilization method

Examples

Experimental program
Comparison scheme
Effect test

manufacture example 1

[0066] Soak 500 g of chopped root of Glycyrrhiza glabra in 5 liters of absolute ethanol, heat under reflux for 2 hours, and extract the soluble components of absolute ethanol. The extract was separated, and the same operation was repeated for the extraction residue to obtain a total of 9.2 liters of the extract. The solvent of the extract was distilled off under reduced pressure, concentrated, and dried to obtain 12.4 g of an oil-soluble licorice extract.

[0067] The typical flavonoid content in the oil-soluble licorice extract obtained in Production Example 1 was quantified by HPLC. As a result, glabricyrrhizic acid was about 40%, and glabriquiritin was about 3%.

manufacture example 2

[0069] Add 10 liters of absolute ethanol to 1 kg of licorice (Glycyrrhiza inflata) root, and extract under reflux for 5 hours. The obtained extract was concentrated under reduced pressure, 10 liters of ethyl acetate was added to the dried residue, and extraction was carried out for 5 hours. The ethyl acetate extract was concentrated under reduced pressure and dried to obtain 30 g of the oil-soluble licorice extract of Production Example 2.

[0070] The typical flavonoid content in the oil-soluble licorice extract obtained in Production Example 2 was quantified by HPLC. As a result, licochalcone A was about 25%.

Embodiment 1

[0072] According to a conventional method, an oil-soluble licorice extract (trade name: "oil-soluble licorice extract P-T (40)" shown in Table 1, manufactured by Maruzen Pharmaceutical Co., Ltd., containing 40% by weight of glycyrrhizic acid, 3% by weight % Glaquiritigenin), sodium metabisulfite (0.005% by weight, 0.01% by weight, 0.05% by weight, 0.1% by weight, and 0.2% by weight), and an emulsion of dipotassium glycyrrhizinate.

[0073] Element

Compounding amount (weight%)

Lipophilic Glyceryl Monostearate

1.0

Polyoxyethylene sorbitan monostearate (20E.O.)

1.0

Polyoxyethylene sorbitan tetraoleate

0.5

stearic acid

0.2

Docosanol

0.4

cetyl palmitate

0.4

Triacane

4.0

Glyceryl tris 2-ethylhexanoate

2.0

Propylparaben

0.1

carboxyvinyl polymer

0.2

1,3-Butanediol

5.0

Oil Soluble Licorice Extract P-T(40)...

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PUM

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Abstract

The composition containing liposoluble licorice extractive for external use can suppress discoloration and stinking-up of the liposoluble licorice extractive, prevent the effective component in the liposoluble licorice extractive from decomposing and suppress gas generation accompanying the decomposing of pyrosulfite and / or sulfite, and has greatly raised stability. It contains liposoluble licorice extractive, at least one of pyrosulfite and sulfite and at least one selected from glycyrrhizic acid, glycyrrhizinate, glycyrrhitic acid and its derivative, and has pH value regulated to 4.5-7.5.

Description

technical field [0001] The present invention relates to the ability to suppress the coloring and odor of oil-soluble licorice extract over time, and to prevent the decomposition of active components of oil-soluble licorice extract such as glabrisin and licochalcone A External preparation composition containing oil-soluble licorice extract which suppresses generation of gas accompanying pyrosulfite and / or sulfite decomposition and greatly improves stability, and stabilization of external preparation composition containing the oil-soluble licorice extract method. Background technique [0002] Oil-soluble licorice extract is extracted from the roots and stems of licorice in the family Fabaceae using solvents such as alcohol and ethyl acetate, and contains a large amount of flavonoids. It is known that this oil-soluble licorice extract has antioxidative effect (refer to JP-A-58-217583), anti-oxidation (refer to JP-A-59-46210), whitening effect (refer to JP-1-149706A). , and Ja...

Claims

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Application Information

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IPC IPC(8): A61K31/35A61K31/56A61K31/704A61P17/00
Inventor 青山知令
Owner MARUZEN PHARMA
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