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Bulleyaconitne drop pill and preparing method thereof

A technology of aconitin and dripping pills, which is applied in the direction of pill delivery, bone diseases, non-central analgesics, etc., and can solve the problems of affecting the therapeutic effect of aconitin, low dissolution rate and dissolution rate, and large proportion of excipients, etc. problems, to achieve the effect of convenient carrying and taking, improved dissolution rate and dissolution rate, and reduced dosage of excipients

Inactive Publication Date: 2004-09-15
HONGYI SCI & TECH CO LTD NANCHANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aconitin is insoluble in water, its tablet disintegrates for a long time, has low dissolution rate and dissolution rate, poor absorption, low bioavailability, large proportion of excipients, and is inconvenient to take for children, the elderly, bedridden patients and patients with dysphagia , poor compliance, affecting the therapeutic effect of aconitin

Method used

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  • Bulleyaconitne drop pill and preparing method thereof

Examples

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Comparison scheme
Effect test

example 1

[0054] prescription:

[0055] Aconitin 0.4g

[0056] Macrogol 6000 20g

[0057] Makes 1000 capsules

[0058] Preparation method: take the ultrafine pulverized and passed through 200-mesh sieve and add it into the molten polyethylene glycol 6000 matrix, stir well, use simethicone oil as coolant, make pellets by drop method, dry, that is have to.

example 2

[0060] prescription:

[0061] Aconitin 0.4g

[0062] Macrogol 4000 20g

[0063] Makes 1000 capsules

[0064] Preparation method: take the ultra-finely pulverized and passed through 200 mesh sieves and add it into the molten polyethylene glycol 4000 matrix, stir well, use simethicone oil as coolant, make pellets by drop method, dry, that is have to.

example 3

[0066] prescription:

[0067] Aconitin 0.4g

[0068] Macrogol 6000 5g

[0069] Macrogol 4000 15g

[0070] Makes 1000 capsules

[0071] Preparation method: take the ultrafine pulverized and passed through 200-mesh sieve and add it into the molten polyethylene glycol 4000 and polyethylene glycol 6000 mixed matrix, stir well, use simethicone as coolant, drop The preparation method is to make pills, dry them, and obtain them.

[0072] 4. Example 4

[0073] prescription:

[0074] Aconitin 0.4g

[0075] Glyceryl monostearate 20g

[0076] Makes 1000 capsules

[0077] Preparation method: take the ultrafine pulverized and passed through 200-mesh sieve and add it into the melted glyceryl monostearate matrix, mix well, use ice water as the cooling agent, make pellets by drop method, and dry to obtain .

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Abstract

The present invention utilizes ultramicropulverization and dripping pill preparation production process to make aconitum kusnezoffi methylsine dripping pills, and can attain the goal of raising disintegration and dissolution speed, quickly obtaining therapeutic effect, raising stability of medicine, reducing dose of auxiliary material, reducing production cost and convenient administration. Said pill not only can be sucked, but also can be swallowed, and its compliance property is good.

Description

technical field [0001] The invention relates to a medicine preparation and a preparation method thereof, in particular to aconitin dripping pills and a preparation method thereof. Background technique [0002] Aconitin has strong analgesic and obvious anti-inflammatory effects. The analgesic effect is mainly central and closely related to the level of serotonin in the brain. The onset time is slower than that of morphine, but the maintenance time is long. Addictive; its anti-inflammatory effect does not pass through the adrenal system, but is related to the suppression of PG levels; it has antipyretic and local anesthetic effects. [0003] Aconitin has the highest content in the liver and adrenal gland, followed by the kidney, lung, spleen and heart, and the brain content is very low. 4 hours after administration, the content in each organ decreased by 50%, and 46% of a dose was excreted from the urine and 21.9% from the feces within 6 days; no metabolic peak was found in t...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/439A61P19/00A61P19/02A61P29/00
Inventor 钱进许军彭红李平朱丹刘孝乐
Owner HONGYI SCI & TECH CO LTD NANCHANG