Oral disintegrating tablet of bambuterol hydrochloride and its preparation method

A technology of bambuterol hydrochloride and orally disintegrating tablets, which is applied in the fields of pill delivery, respiratory system diseases, and active ingredients of esters. Good therapeutic effect and disintegration performance

Active Publication Date: 2004-11-17
CHENGDU SHENGNUO BIOTEC CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, although bambuterol hydrochloride has various oral dosage forms, it is not very convenient for the elderly and children who have certain difficulties in swallowing
For example: In the case of tablets and capsules commonly used as oral preparations, many elderly people and children with poor swallowing ability are reluctant to take these solid dosage forms, complaining of difficulty swallowing medicine or esophageal obstruction, while chewable tablets are also It is also not suitable for the elderly and children with weak chewing ability
As far as powders or granules are concerned, in addition to their difficulty in swallowing, they are also easy to stay in the mouth, resul...

Method used

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  • Oral disintegrating tablet of bambuterol hydrochloride and its preparation method

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] The orally disintegrating tablet of bambuterol hydrochloride includes main ingredients and auxiliary materials, and is characterized in that it is prepared according to the following weight percentages: 5% of main ingredients and 95% of auxiliary materials.

[0043] The orally disintegrating tablet of the present invention is prepared from the following raw materials in weight ratio:

[0044] Bambuterol Hydrochloride 5.0g

[0045] Lactose 44.0g

[0046] Mannitol 17.5g

[0047] Microcrystalline Cellulose 21.6g

[0048] Low-substituted hydroxypropyl cellulose 2.4g

[0049] Cross-linked polyvinylpyrrolidone 5.0g

[0050] Sodium bicarbonate 1.0g

[0051] Citric acid 1.0g

[0052] Aspartame 0.5g

[0053] Mint essence 0.25g

[0054] Cherry essence 0.75g

[0055] Magnesium Stearate 1.0g

[0056] A total of 1000 tablets were produced

[0057] Among them, lactose and mannitol are fillers. Low-substituted hydroxypropyl cellulose, microcrystalline cellulose and cross-l...

Embodiment 2

[0067] The orally disintegrating tablet of bambuterol hydrochloride includes main ingredients and auxiliary materials, and is characterized in that it is prepared according to the following weight percentages: 10% of main ingredients and 90% of auxiliary materials.

[0068] The orally disintegrating tablet of the present invention is prepared from the following raw materials in weight ratio:

[0069] Bambuterol Hydrochloride 10.0g

[0070] Lactose 40.0g

[0071] Mannitol 20.0g

[0072] Microcrystalline Cellulose 20.0g

[0073] Low-substituted hydroxypropyl cellulose 4.0g

[0074] Cross-linked polyvinylpyrrolidone 5.0g

[0075] Sodium bicarbonate 1.0g

[0076] Citric acid 1.0g

[0077] Aspartame 0.5g

[0078] Mint essence 0.25g

[0079] Cherry essence 0.75g

[0080] Magnesium Stearate 1.0g

[0081] A total of 1000 tablets were produced

[0082] Among them, lactose and mannitol are fillers. Low-substituted hydroxypropyl cellulose, microcrystalline cellulose and cross...

Embodiment 3

[0094] The orally disintegrating tablet of bambuterol hydrochloride includes main ingredients and auxiliary materials, and is characterized in that it is formulated according to the following weight percentages: 20% of main ingredients and 80% of auxiliary materials.

[0095] The orally disintegrating tablet of the present invention is prepared from the following raw materials in weight ratio:

[0096] Bambuterol Hydrochloride 20.0g

[0097] Lactose 10.0g

[0098] Mannitol 27.0g

[0099] Microcrystalline Cellulose 15.0g

[0100] Low-substituted hydroxypropyl cellulose 10.0g

[0101] Cross-linked polyvinylpyrrolidone 3.0g

[0102] Sodium bicarbonate 5.0g

[0103] Citric acid 5.0g

[0104] Aspartame 1.0g

[0105] Mint essence 0.15g

[0106] Cherry essence 0.85g

[0107] Magnesium stearate 0.5g

[0108] A total of 1000 tablets were produced

[0109] Among them, lactose and mannitol are fillers. Low-substituted hydroxypropyl cellulose, microcrystalline cellulose and cr...

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Abstract

The invention discloses a Bambuterol Hydrochloride oral disintegration tablet, wherein the principal drug employs Bambuterol Hydrochloride, the auxiliary materials include lactose, mannitol, crystalline cellulose, low replacement methylcellulose propylene glycol ether, cross bonding polyvinyl pyrrolidon, sodium hydrogen carbonate, citric acid, Aspartame, perfume compound, and magnesium stearate. The tablet has good treatment action for bronchial asthma, chronic bronchitis and pulmonary emphysema.

Description

Technical field: [0001] The invention relates to an oral pharmaceutical preparation for treating asthma and a preparation method thereof, in particular to a bambuterol hydrochloride orally disintegrating tablet capable of rapidly disintegrating, releasing and masking bad smell and a preparation method thereof. Background technique: [0002] Babuterol hydrochloride is a long-acting β2-receptor stimulant and is currently the longest-acting bronchodilator. After oral administration, it can be preferentially distributed in the lung tissue, and slowly hydrolyzed in the lung tissue to produce terbutaline, thereby maintaining a balanced and continuous plasma concentration in the blood. Oral once a night, the action time can reach 24 hours. [0003] Babuterol hydrochloride is a new generation of asthma medicine, which has the advantages of super long-acting, small side effects, and convenient administration. It has great medical value for asthma patients who are prone to attacks at...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/27A61P11/06
Inventor 谢期林谢海峰马进
Owner CHENGDU SHENGNUO BIOTEC CO LTD
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