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Ribavirin oral drop pill and preparing process

A ribavirin and preparation technology, which is applied in the field of ribavirin oral drop pills and preparation, can solve the problems that the effect is not fully exerted, and achieve the effect of increased bioavailability, small dosage, and rapid drug effect

Inactive Publication Date: 2004-12-15
许军
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no preparation that utilizes ribavirin to make oral drop pills, and its effectiveness has not been brought into full play.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Prescription: Ribavirin 5.0g

[0016] Polyethylene glycol 6000 15.0g

[0017] Macrogol 4000 5.0g

[0018] Poloxamer 0.5g

[0019] Made into 1000 capsules, with an average of 5.0mg of ribavirin per capsule

[0020] Add 5.0 g of ribavirin to 15.0 g of polyethylene glycol 6000, 0.5 g of poloxamer of 5.0 g of polyethylene glycol 4000, heat, melt and mix well, then add 60 drops per minute at 70°C-100°C Drop it into the condensation of simethicone oil at a high speed. After forming, take it out, remove the condensing agent, check the amount of ingredients, and pack it to get the finished product. Every 1000 ribavirin dripping pills contains 5.0g of ribavirin.

[0021] The inspection method is: this product is a white dropping pill. The content determination method is high-performance liquid chromatography, using octadecylsilane bonded silica gel as a filler, and water as a mobile phase; the detection wavelength is 207nm, and the number of theoretical pl...

Embodiment 2

[0024] Prescription: Ribavirin 6.0g

[0025] Polyoxyethylene monostearate 10.0g

[0026] Polyethylene glycol 6000 5.0g

[0027] Made into 1000 capsules, with an average of 6.0mg of ribavirin per capsule

[0028] Add 6.0g of ribavirin to 5.0g of polyethylene glycol 6000, 10.0g of polyoxyethylene monostearate, heat, melt and mix well, then drop at a rate of 100 drops per minute at 80°C-100°C Put it into liquid paraffin condensate oil, after forming, take it out, remove the condensing agent, check the amount of ingredients, and pack it to get the finished product. Every 1000 ribavirin dripping pills contains 6.0g of ribavirin.

[0029] The inspection method is: this product is a white dropping pill. The content determination method is high-performance liquid chromatography, using octadecylsilane bonded silica gel as a filler, and water as a mobile phase; the detection wavelength is 207nm, and the number of theoretical plates is not less than 2500 based on ri...

Embodiment 3

[0032] Prescription: Ribavirin 8.0g

[0033] Polyoxyethylene monostearate 10.0g

[0034] Macrogol 4000 3.0g

[0035] Made into 1000 capsules, each capsule contains 8.0mg of ribavirin on average

[0036] Add 8.0g of ribavirin to 3.0g of polyethylene glycol 4000 and 10.0g of polyoxyethylene monostearate, heat, melt and mix well, then drop at a rate of 30 drops per minute at 85°C-100°C Put it into the vegetable oil condensate oil, after forming, take it out, remove the condensing agent, check the component quantity, pass it, pack it, and get the finished product. Every 1000 ribavirin dripping pills contains 8.0g of ribavirin.

[0037] The inspection method is: this product is a white dropping pill. The content determination method is high-performance liquid chromatography, using octadecylsilane bonded silica gel as a filler, and water as a mobile phase; the detection wavelength is 207nm, and the number of theoretical plates is not less than 2500 based on rib...

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PUM

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Abstract

The orally taken Ribavirin dropping pill contains Ribavirin 1-12 mg each and proper amount of matrix. The matrix may be one of polyglycol-6000, polyglycol-4000, polyoxyethylene monostearate, sodium stearate, etc. or their composition. The preparation process includes mixing Ribavirin and heated and smelted matrix, dropping the mixture at 50-120 deg.c into condensing agent to form dropping pill, eliminating condensing agent, inspection and packing. The condensing agent is one or several of dimethyl silicon oil, liquid paraffin, rape seed oil and tea seed oil. The Ribavirin dropping pill may be used in preventing and treating viral respiratory tract infection and other viral infection, and has the features of high efficiency and less side effect.

Description

technical field [0001] The invention relates to an oral drop pill, in particular to a ribavirin oral drop pill with broad-spectrum antiviral infection and a preparation method thereof. Background technique [0002] The chemical name of ribavirin is 1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide. It is colorless or white crystalline powder, odorless and tasteless. This product is a broad-spectrum antiviral drug. Its mechanism of action is mainly through the inhibition of inosine dehydrogenase, blocking the conversion of inosine-phosphate to xanthine-phosphate, inhibiting nucleic acid synthesis, and preventing virus replication. Clinically, it is mainly used to prevent and treat a variety of viral respiratory infections and other viral infections, such as influenza and herpes zoster. Ribavirin Oral Dropping Pills refers to a preparation made by heating, melting and mixing ribavirin and related bases, then dropping them into an immiscible condensing agent, shrinking and co...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/7056A61P31/12
Inventor 许军彭红
Owner 许军
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