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Resina draconis and its total flavone solution preparation and its preparation method

A total flavonoids and solution-type technology, applied in the field of medicine, can solve the problems of inconvenient external use, waste, organic solvent residue, etc., to achieve convenience for medical workers and patients, improve absorption and utilization, and reduce irritation

Inactive Publication Date: 2005-02-16
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Conventional preparations are prepared from dried blood powder (original powder of dried blood). Since dried dried blood is insoluble in water, it is rarely absorbed in the body, and most of it is excreted from the body, resulting in waste; Dried blood powder is made into a paste with alcohol and applied to the affected area, which will also cause waste
There is a patent (ZL00114031.0, CN1096852C) using a solid dispersant to disperse dried blood to improve absorption, but the dispersant used in this patent is cyclodextrin and polyethylene glycol with a molecular weight of 1000-20000. Low-molecular alcohol (ethanol, isopropanol) and acetone solvent disperse the blood, and finally remove the solvent with low-temperature drying, vacuum drying or vacuum freeze-drying technology, so that not only increases the cost, but also has the residual problem of organic solvents, and, After the solvent is removed, dried blood is dispersed in the dispersant in the form of tiny particles (not in a molecular state), although the efficacy of the medicine has been improved, but there are still problems of poor absorption and inconvenient external use
Recently, some authors have applied for the preparation process and new application of the total flavonoids of blood jellyfish (application number: 02129688.X), but there is no report on the formulation and preparation process of the total flavonoids of blood type jellyfish

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0007] Embodiment 1: the preparation of dried blood (total flavonoids of dried blood) solution

[0008] prescription:

[0009] ·Blood Dragon (Total Flavonoids of Blood Dragon) 10g(1g)

[0010] Polyethylene glycol 200 (PEG200) 20g

[0011] Preparation Process:

[0012] Weigh the prescribed amount of polyethylene glycol 200 and dried blood (total flavonoids of dried dried blood), put them in a beaker, heat at 70-80°C, stir to dissolve, cool to room temperature, and filter to obtain a solution. The obtained solution can be prepared into soft capsules (including enteric-coated and colon-targeted), hard capsules (including enteric-coated and colon-targeted), solutions and the like.

Embodiment 2

[0013] Embodiment 2: the preparation of dried blood (total flavonoids of dried blood) solution

[0014] prescription:

[0015] Blood Dragon (Total Flavonoids of Blood Dragon) 10g(1g)

[0016] Polyethylene glycol 400 (PEG400) 30g

[0017] Polyethylene glycol 6000 1g

[0018] Soy Lecithin 1g

[0019] Water 0.2g

[0020] Preparation Process:

[0021] Weigh the prescribed amount of polyethylene glycol 400, polyethylene glycol 6000, soybean lecithin, and dried blood (total flavonoids of dried blood), put them in a beaker, heat at 65-75°C, stir to dissolve, add water, and mix well , cooled to room temperature, filtered to obtain a solution. The obtained solution can be prepared into soft capsules (including enteric-coated and colon-targeted), hard capsules (including enteric-coated and colon-targeted), solutions, injections, and the like.

Embodiment 3

[0022] Embodiment 3: the preparation of dried blood (total flavonoids of dried blood) solution

[0023] prescription:

[0024] Blood Dragon (Total Flavonoids of Blood Dragon) 10g(2g)

[0025] Polyethylene glycol 400 (PEG400) 30g

[0026] Propylene glycol 1g

[0027] Ethanol 1g

[0028] Egg yolk lecithin 15g

[0029] Water 0.2g

[0030] Preparation Process:

[0031] Weigh the prescribed amount of polyethylene glycol 400, propylene glycol, ethanol, egg yolk lecithin, and dried blood (total flavonoids of dried dried blood), put it in a beaker, heat to 70°C, stir to dissolve, add water, mix well, and cool to room temperature , filtered to obtain a solution. The obtained solution can be prepared into soft capsules (including enteric-coated and colon-targeted), hard capsules (including enteric-coated and colon-targeted), solutions, injections, and the like.

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PUM

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Abstract

The invention discloses a dragon's blood and flavone solution preparations and its manufacturing method. It solves the problem that the normal preparation only uses the dragon's blood powder, and it upgrades the curative effect of dragon's blood, and reduces the loss in external use, reduces the stimulation of the dragon's blood particles. It produces solution type dragon's blood through polyethylene glycol solution, phospholipids and other compound solutions, the weight proportion of the polyethylene glycol solution and the medicine is 1:2-100:1, the polyethylene glycol is the one with molecular of 200-6000. The technology can be produced into solution soft capsule (including intestine dissolution type and colon target direction type), hard capsule solution (including intestine dissolution type and colon target direction type), solution and plaster and injection solution and so on.

Description

Technical field: [0001] The invention relates to the technical field of medicines, in particular to a solution-type preparation of dried blood and total flavonoids of dried dried blood and a preparation method thereof. Background technique: [0002] Dracaena, also known as dragon's blood, is extracted from the resin of the dracaena tree, and is praised as a holy medicine for promoting blood by "Compendium of Materia Medica". Its pharmacological effects are as follows: (1) Improve the microcirculation of the body, promote blood circulation and remove blood stasis, increase blood coagulation factors in the body, have significant hemostatic effect on bleeding patients, have two-way regulating effect on TCM blood disorders, promote metabolism, and accelerate lymphatic return. (2) Increase coronary artery flow, reduce blood viscosity, improve blood quality, inhibit platelet aggregation, improve hemorheology abnormalities, and treat and prevent cardiovascular and cerebrovascular d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K9/08A61K9/48A61K31/7048A61P17/02A61P17/04A61P19/08A61P29/00
Inventor 邓意辉徐峰吴琼
Owner SHENYANG PHARMA UNIVERSITY
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