Niclosamide ethanolamine salt powder and its preparation method

A technology of niclosamide ethanolamine salt and ethanolamine salt powder, which is applied in the field of pesticide manufacturing, can solve problems such as constraints and lack of water for molluscicide, and achieve labor saving, significant social and economic benefits, and a wide range of applications

Active Publication Date: 2005-06-01
JIANGSU INST OF PARASITIC DISEASES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because oncomelanias are amphibious freshwater snails, they are mainly distributed in complex environments such as river ditches, rivers and lakes, beaches, and hilly mountains. About 70% of the breedin

Method used

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  • Niclosamide ethanolamine salt powder and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] In the embodiment of the present invention, 3.6% by weight of niclosamide ethanolamine salt, 1.2% by weight of sodium lignosulfonate, and 0.3% by weight of sodium dodecylbenzenesulfonate are added to the universal pulverizer for mixing and pulverization, and the loading rate of the mixer is 35-40%; the rotary speed of the mixer is 10-15r / min, and the mixing and crushing time is 20-25min / time; the powder semi-finished product and filler after the above crushing are selected from 180 mesh / inch kaolin: 94.9% by weight, and its total content Add the middle part into the horizontal ribbon mixer and mix evenly, the mixing ratio is 1:4, make 20% intermediate concentration powder, and check; then mix the intermediate concentration powder with remaining 180 mesh / inch kaolin (water content < 1%) is mixed evenly for the second time by 1: 4 to make 4% niclosamide ethanolamine salt powder, and then pulverized for the second time, the loading rate of the mixer is 35-40%; the speed of ...

Embodiment 2

[0037]In the embodiment of the present invention, take 4% by weight of niclosamide ethanolamine salt, 1.1% by weight of sodium lignosulfonate, and 0.2.5% by weight of sodium dodecylbenzenesulfonate and add them into a Raymond mill for mixing and pulverization. The loading rate is 35-40%; the rotation speed of the mixer is 10-15r / min, and the mixing and crushing time is 20-25min / time; the above-mentioned pulverized powder semi-finished products and fillers are selected from 180 mesh clay (water content <1%) : 94.65% by weight, part of its total content is added into a horizontal ribbon mixer and mixed uniformly, its mixing ratio is 1:4, and 20% intermediate concentration powder is made, and tested; then the intermediate concentration powder and multiplied The remaining 180 mesh potter's clay is mixed evenly for the second time at 1:4 to make 4% niclosamide ethanolamine salt powder, and then pulverized for the second time. The loading rate of the mixer is 35-40%; the rotation spe...

Embodiment 3

[0039] In the embodiment of the present invention, 4.4% by weight of niclosamide ethanolamine salt, 1.0% by weight of sodium lignosulfonate, 0.2% by weight of sodium dodecylbenzenesulfonate, and 180 mesh pottery clay (water content<1%) are used as filling materials. : 94.4% by weight. The proportioning of the above-mentioned components adopts the production process in the first and second examples, and the above-mentioned oncomelania killing effect can also be obtained after two times of crushing and two times of mixing.

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Abstract

The present invention relates to one kind of niclosamide ethanolamine salt powder preparation and its preparation process, and belongs to the field of pesticide producing technology. Niclosamide ethanolamine salt is used as molluscacide for controlling and eliminating schistosomiasis. Niclosamide ethanolamine salt, sodium lignosulfonate and dodecyl sodium bensosulfonate are first mixed and crushed; the mixing powder is then mixed with partial stuffing of 4 times to form the intermediate mixture; and the intermediate mixture is finally with other stuffing and the mixture is crushed to obtain the finished product. The present invention has high effect of killing watersnail, including watersnail and its egg.

Description

technical field [0001] The invention relates to niclosamide ethanolamine salt powder and a preparation method thereof, which is mainly used for killing snails, the intermediate host of schistosomiasis, and controlling and eliminating schistosomiasis, and belongs to the technical field of pesticide manufacturing. Background technique [0002] Schistosomiasis is a parasitic disease that seriously endangers human health. China is one of the four countries where schistosomiasis is most prevalent in the world. There are 12 million patients and about 100 million people at risk. Oncomelania is the only intermediate host of Schistosoma japonicum, eradicating Oncomelania can control and eliminate schistosomiasis. Niclosamide is the only molluscicide recommended by the World Health Organization (WHO). Because the drug is insoluble in water, it is made into ethanolamine salt. Currently, the snail-killing drug used in the field is mainly 50% niclosamide ethanolamine salt wettable powd...

Claims

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Application Information

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IPC IPC(8): A01N25/12A01N37/48
Inventor 黄轶昕孙乐平洪青标
Owner JIANGSU INST OF PARASITIC DISEASES
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