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Injection of flurbiprofen and its preparing method

A flurbiprofen axetil and solvent refining technology, applied in pharmaceutical formulations, antipyretics, drug delivery, etc., can solve problems such as affecting clinical use, gastrointestinal disorders, patients unable to take drugs orally, and achieve less gastric mucosal damage. , The effect of improving pain symptoms and very low incidence of adverse reactions

Inactive Publication Date: 2005-06-01
梁建华
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  • Summary
  • Abstract
  • Description
  • Claims
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Problems solved by technology

At present, most of the preparations on the market are oral preparations. It has been found that oral administration of flurbiprofen can easily cause adverse reactions such as gastrointestinal disorders, and when treating postoperative pain or pain caused by cancer, most patients cannot take oral medicines, which affects clinical use. , so it is necessary to develop other dosage forms of flurbiprofen, such as intravenous dosage forms

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0005] The preferred prescription of the present embodiment is as follows:

[0006] 1. Prescription composition:

[0007] Flurbiprofen axetil 50g main drug

[0008] Refined Soybean Oil 600g Solvent

[0009] Refined Lecithin 70g Emulsifier

[0010] Glycerin 112g Isotonic

[0011] Disodium hydrogen phosphate 4.2g Buffer

[0012] citric acid pH adjuster

[0013] Add water for injection to 50000ml medium

[0014] Pour flurbiprofen axetil, refined soybean oil and refined lecithin weighed according to the prescription into the coarse emulsification tank (feeding according to 105% of the prescription amount), keep warm at 50-60°C, stir for 10 minutes, and rotate at a speed of 2500- 3000rpm, mix and dissolve, then add the calculated amount of water for injection and concentrated glycerin, keep warm at 50-60°C, and stir for 20 minutes to make a coarse emulsion. Pour the coarse emulsion into the homogenizer, homogenize under high pressure, keep 700-750kg / cm 3 of high pressure. ...

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PUM

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Abstract

The present invention is flurbiprofen ester injection as antiphlogistic and analgetic medicine and its preparation process. Main medicine and supplementary material including solvent, emulsifier, isotonic agent, buffering agent and pH regulator are mixed to compound the injection. Compared with available oral flurbiprofen preparation, the flurbiprofen ester injection has even high curative effect, even fast action, long lasting effect and less stomach mucous membrane damage and other negative effect. The present invention is used in treating chronic rheumarthritis, etc and is especially suitable for relieve post-operational pain and pain caused by cancer, and it has high effect and no addiction.

Description

technical field [0001] The invention relates to a flurbiprofen axetil injection dosage form and a preparation method thereof. Background technique [0002] Flurbiprofen axetil (Flurbrofene axetil) is the acetoxyethyl ester of flurbiprofen, which can be hydrolyzed by carboxyl esterase in vivo to produce flurbiprofen, which inhibits the synthesis of prostaglandins. Flurbiprofen is a non-steroidal anti-inflammatory drug (NSAID) widely used clinically. It has anti-inflammatory, analgesic and antipyretic effects, and is clinically used for the treatment of pain or inflammatory diseases. In 1998, my country approved the listing of flurbiprofen raw materials and tablets of Shanghai Sanwei Pharmaceutical Co., Ltd., and its raw drug approval number is: Guoyao Zhunzi (1998) X-362, which is used for the treatment of rheumatoid arthritis. Sustained-release tablets and eye drops (used to inhibit miosis during intraocular surgery and postoperative anti-inflammati...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/216A61P29/00
Inventor 梁建华
Owner 梁建华
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