Gynostemme pentaphylium soft capsule and its preparing process

A technology of Gynostemma pentaphyllum and soft capsule, which is applied in capsule delivery, medical preparations containing active ingredients, digestive system, etc. It can solve problems such as difficulty in making oral liquid preparations, long disintegration time of tablets, and reduction of the expected curative effect. Achieve the effects of retaining medicinal value, easy long-term storage, and reducing production costs

Inactive Publication Date: 2005-07-06
仵博
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the long disintegration time of the tablet in the body, the bioavailability is low, and the curative effect should be reduced.
Gypenosides have a bitter taste and are not easy

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0006] The present invention will now be described in detail in conjunction with examples:

[0007] This embodiment is made of the following raw materials by weight percentage:

[0008] Shell: gelatin 40.77%, glycerol 14.26%, polyethylene glycol-400 4.08%, methyl paraben 0.12%, purified water 40.77%

[0009] Encapsulation solution: Gynostemma total glycosides 20%, polyethylene glycol-400 70%, propylene glycol 10%

[0010] Preparation Process:

[0011] 1. Crush the total glycosides of Gynostemma to a particle size of 120 mesh or more for later use;

[0012] 2. Take polyethylene glycol-400 and propylene glycol and mix for later use. Place the raw materials of Gynostemma pentaphyllum in a sandwich stainless steel water bath, add the mixed liquid and stir and heat to 60~70℃, filter after the raw materials of Gypenosides are dissolved, and reduce the filtrate. After pressing and degassing, it becomes a encapsulated liquid, ready for use;

[0013] 3. Put the gelatin in a sandwich stainl...

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Abstract

The invention discloses a gynostemme pentaphylium soft capsule and its preparing process, wherein the capsule includes capsule shell and capsule liquid, wherein the capsule shell comprises gelatin, glycerin, methyl hydroxybenzoate and purified water, wherein the percentages by weight of the compositions is 1:0.35:0.1:0.003:1, while the capsule liquid comprises gynostemma pentaphylla triterpenes, polyethylene glycol -400 and propylene glycol by the weight percent of 2:7:1. The medicinal granules are obtained from allocated capsule shell and capsule liquid in the soft capsule making machine.

Description

technical field [0001] The invention relates to a gypenoside soft capsule and a preparation process thereof, belonging to the capsule preparation technology. Background technique [0002] Clinical studies have proved that Gynostemma pentaphyllum has obvious strengthening effects, anti-fatigue, prolonging cell life, lowering blood lipid levels, and treating various cancers, and has certain preventive effects on cancer, ulcers, migraines and other symptoms. It is widely used in hypertension, hyperlipidemia, gastric ulcer and other diseases, and has achieved certain curative effect: Gypenosides Tablets have significant curative effect in reducing serum cholesterol, triglyceride and low-density lipoprotein cholesterol, and increasing high-density lipoprotein cholesterol , the total effective rate is 94.8%. However, due to the long disintegration time of the tablet in the body, the bioavailability is low, and the curative effect should be reduced. Gypenosides have a bitter tast...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K31/704A61P1/04A61P3/06A61P9/12
Inventor 仵博
Owner 仵博
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