Dahurian rhododendron leaf extract and extracting method thereof

An extraction method and extract technology, which can be used in drug combinations, pharmaceutical formulas, respiratory diseases, etc., can solve the problems of high ointment yield, inability to obtain exact characterization of high-purity extracts, etc., and achieve convenience in taking and good drug development prospects , less toxic effect

Inactive Publication Date: 2005-07-06
李青山
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The present invention aims at the problem that the high-purity extracts that cannot be accurately characterized at present, and thus Manshanhong is used as crude drug or crude extract as medicine, and provides a kind of Manshanhong (high purity) with exact characterization and outs

Method used

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  • Dahurian rhododendron leaf extract and extracting method thereof
  • Dahurian rhododendron leaf extract and extracting method thereof
  • Dahurian rhododendron leaf extract and extracting method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] Example 1. Preparation of Manshan Red Extract

[0066] 1. Extract

[0067]Take Manshanhong original medicinal material (300g of dried stems and leaves), crush it, and extract 3 times (3000ml×3) with 3000ml of 40% ethanol aqueous solution reflux at 85℃-100℃ for 1hr each time. Combine the extracts. Let stand overnight at room temperature, filter, and remove precipitation. The filtrate is concentrated under reduced pressure (55℃, 0.08-0.1MPa) to a total volume of 1800ml. The concentrated solution is added with 1% gelatin aqueous solution 540ml (equivalent to 5.4g gelatin, which can be made into other low Concentration of gelatin aqueous solution, as long as the gelatin is fully dissolved), stir, stand at room temperature for 4-8hr, filter with suction, discard the residue, and pass the supernatant through the treated polyamide resin column (column volume about 400ml, flow rate 400ml / hr ), spray a thin layer of polyamide with 95% ethanol solution of aluminum trichloride for col...

Embodiment 2

[0081] Example 2. Preparation of Manshan Red Extract

[0082] 1. Extract

[0083] Take the Manshanhong original medicinal material (300g of dried stems and leaves) that is different from that of Example 1 in the place of origin and harvest season, crush it, and extract 3 times (3000ml×3) with 3000ml of 60% ethanol aqueous solution under reflux at a temperature of 85℃-100℃ ), 1hr each time, combine the extracts, let stand overnight at room temperature, filter, remove precipitation, and concentrate the filtrate under reduced pressure (55℃, 0.08-0.1MPa) to a total volume of 1800ml, and add 270ml of 1% chitosan solution to the concentrate , Stir, add 270ml of 1% gelatin aqueous solution, stir, let stand at room temperature for 4-8hr, filter with suction, discard the residue, and pass the supernatant through the treated polyamide resin column (column volume about 400ml, flow rate 400ml / hr), The thin layer of polyamide is sprayed with aluminum trichloride 95% ethanol solution for color ...

Embodiment 3

[0097] Example 3. Preparation of Manshan Red Extract

[0098] 1. Extract

[0099] Take the Manshanhong original medicinal material (300g of dried stems and leaves) that is different in origin and harvest season from Examples 1 and 2, crush it, and extract 3 times with 3000ml of 60% ethanol aqueous solution under reflux at a temperature of 85℃-100℃ (3000ml ×3), 1hr each time, combine the extracts, let stand overnight at room temperature, filter, remove precipitation, and concentrate the filtrate under reduced pressure (55℃, 0.08-0.1MPa) to a total volume of 1800ml, and add 1% ZTC1 to the concentrated solution for clarification. Add 216ml of reagent B component, stir, then add 108ml of 1% ZTC clarifier component A, stir, let stand at room temperature for 4-8hr, filter with suction, discard the residue, and pass the supernatant through the treated polyamide resin column (column volume About 400ml, flow rate 400ml / hr), spray a thin layer of polyamide with 95% ethanol solution of alumi...

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Abstract

The invention relates to the extracting process for Dahurian rhododendron leaf extract and extracting method, wherein the extract comprises, flavones 30-90% (measured by using hyperin as the representing compostion), hyperin compound 6.3-42%, farrerol 0.4-8%, quercetin compound 0.7-7%, the extraction method comprises employing polyamide resin separating column, clarifying the liquid with clearing agent and purifying.

Description

Technical field [0001] The invention relates to a Manshanhong extract and an extraction method thereof, in particular to a flavonoid substance extracted from Manshanhong and an extraction method for such flavonoid substances. Background technique [0002] Manshanhong is the dry leaves of Rhododendron dauricum L (Rhododendron dauricum L), also known as Dazixiang, Azalea and Yingshanhong. It is a natural medicine with a wide range of pharmacological effects. The traditional Chinese medicine Manshanhong has the effects of relieving cough, expectorating and relieving asthma. It is used to treat acute and chronic bronchitis and asthma. Its effective ingredients are flavonoids. Among the Manshanhong products currently on the market, there are preparations that use Manshanhong crude drug or crude extract as medicine, such as "Manshanhong Oil Dropping Pills" and "Xiaokechuan Syrup". The compound preparation that uses Manshanhong as medicine is "Qin Baohong Capsule" (main ingredients: Man...

Claims

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Application Information

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IPC IPC(8): A61P11/00
Inventor 李青山张振杰韩玲革李晓妮
Owner 李青山
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