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Reduced glutathione soft capsule and manufacturing process thereof

A technology of glutathione and reduced form, which is applied in capsule delivery, tripeptide components, anti-toxic agents, etc., can solve problems such as poor compliance, instability of tablets and buccal tablets, and achieve improved stability and high patient compliance , the effect of masking the special smell

Inactive Publication Date: 2005-07-06
北京瑞伊人科技发展有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Reduced glutathione currently on the market is reduced glutathione for injection, which is not as convenient as oral preparations for clinical use, and patients suffer from certain pains and poor compliance. Currently, reduced glutathione tablets are under development and research and buccal tablets, but because reduced glutathione is easily oxidized to oxidized glutathione in the air, and has strong hygroscopicity, it is less stable when made into tablets and buccal tablets

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Grind 200g of reduced glutathione, 0.2g of folic acid and 200g of dextrin respectively, pass through a 100-mesh sieve, and mix well. Use 80% ethanol to make soft material and 20-mesh sieve to granulate the mixture. Dry at 60°C until the water content is 0.5-2.5%, granulate with a 16-mesh screen, choose moisture-proof and anti-oxidation coating powder to coat the granules, control the pot temperature at 45-60°C, and control the speed of the pot at 15-25rpm. According to the 3% weight gain of the granules, a concentration of 12.5% ​​alcohol-soluble coating solution is formulated, sprayed and coated with the liquid at an appropriate flow rate, after the coating is finished, air-dried, and the coated granules are packed into capsules.

Embodiment 2

[0049]Grind 100g of reduced glutathione, 0.06g of vitamin C and 200g of starch respectively, pass through a 100-mesh sieve, and mix evenly. The mixed material is granulated with a soft material made of 70% ethanol and a 20-mesh sieve. Dry at 60°C until the water content is 0.5-2.5%, granulate with a 16-mesh screen, choose moisture-proof and anti-oxidation coating powder to coat the granules, control the pot temperature at 45-60°C, and control the speed of the pot at 15-25rpm. According to the 3% weight gain of the granules, a concentration of 12.5% ​​alcohol-soluble coating solution is formulated, sprayed and coated with the liquid at an appropriate flow rate, after the coating is finished, air-dried, and the coated granules are packed into capsules.

Embodiment 3

[0051] 200g reduced glutathione, 0.18g folic acid and 400g pregelatinized starch were pulverized respectively, passed through a 100 mesh sieve, mixed evenly, the mixed material was granulated with 80% ethanol as a soft material, and a 20 mesh sieve was granulated. ℃~60℃, dry until the moisture is 0.5-2.5%, granulate with 16 mesh screen, choose moisture-proof and anti-oxidation coating powder to coat the granules, control the temperature of the pot at 45-60 ℃, and the speed of the pot at 15- 25rpm, according to 3.25% of granule weight gain, be made into concentration and be 12.5% ​​alcohol soluble coating liquid, spray liquid coating with appropriate flow rate, after coating finishes, dry in the air, get the granule after coating and pack capsule.

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PUM

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Abstract

The invention discloses a kind of reduced glutathione capsule and manufacturing process, wherein the product comprises granule and capsule shell, wherein each content capsule contains 100-500mg of reduced glutathione, bulking agent, binding agent and anti-oxidizing agent, a particle dressing process is also employed. The capsule has the advantages of good compliance for patients and better constancy.

Description

technical field [0001] The invention relates to reduced glutathione capsules and a preparation method thereof, belonging to the technical field of medicines and their preparation. technical background [0002] Reduced glutathione is an important component of all cells. It has two main physiological functions, one is anti-oxidation, and the other is integrated detoxification. It can scavenge free radicals and restore other used antioxidants so that they can be recycled; the active group thiol in the reduced glutathione molecule can combine with certain substances to have an integrated detoxification effect. It is mainly used clinically for detoxification, radiation sickness, radiation protection, and liver protection. Reduced glutathione currently on the market is reduced glutathione for injection, which is not as convenient as oral preparations for clinical use, and patients suffer from certain pains and poor compliance. Currently, reduced glutathione tablets are under deve...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K38/06A61P1/16A61P17/16A61P39/02A61P39/06
Inventor 孙丽红王嘉瑜庄大伟王卓睿张志宏
Owner 北京瑞伊人科技发展有限公司
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