Method for preparing cefathiamidide

Abstract

The preparation process of cefathiamidine includes the following two synthesis steps: 1) preparing cefathiamidine acid through the reaction between 7-ACA and bromoacetyl bromide, acidifying, solvent extraction, concentration and drying; and 2) preparing cefathiamidine product through adding alkali reagent to dissolve cefathiamidine acid, reaction with diisopropyl thiourea, and adding semi-soluble solvent to separate out cefathiamidine product. The said preparation process has less steps, and is simple and feasible.

Description

technical field

[0001] The invention relates to the field of chemical drug synthesis, in particular to a preparation method of the chemical raw material drug cefathiamidine. Background technique

[0002] Cefathiamidine (Cefathiamidine) is the first generation cephalosporin, which was first created and used clinically in my country.

[0003]

[0004] Commonly known as: pioneer mycin 18, cephalosporin 18. The antibacterial spectrum is similar to that of cephalothin, and it has a stronger effect on Staphylococcus aureus, Streptococcus viridans, and Pneumococcus, and has unique antibacterial activity against Enterococcus, and is mainly used for respiratory tract infections caused by Staphylococcus aureus, Pneumococcus, and Streptococcus, Biliary tract infection, urinary tract infection, gynecological infection, sepsis, pneumonia, meningitis and other infections. In my country, only Guangzhou Baiyunshan Chemical Pharmaceutical Factory produces it. USP3,646,025 and "Chinese ...

Images